Immunohistochemical study of idiopathic histiocytosis of the mandible and maxilla

Jeffery Stewart, Joseph A. Regezi, Ricardo V. Lloyd, Kenneth D. McClatchey

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Recent evidence suggests that the proliferative cells of idiopathic histiocytosis may be derived from Langerhans cells. In this study, antisera to S-100 protein, HLA-DR (la-like) antigen, muramidase, and α1-antichymotrypsin were tested on formalin-fixed, paraffin-embedded tissue from nine cases of idiopathic histiocytosis using an immunoperoxidase technique. Tumor cells were positive for S-100 protein and HLA-DR antigen but negative for muramidase and α1-antichymotrypsin. Mononuclear phagocytes were positive for HLA-DR antigen, muramidase, and α1-antichymotrypsin but negative for S-100 protein. The immunohistochemical staining pattern of the tumor cells in these cases of idiopathic histiocytosis is similar to that seen for normal Langerhans cells. When these results are coupled with electron microscopic and histochemical data, it would appear that the origin of cells in idiopathic histiocytosis is from the Langerhans cell or its precursor. Thus, this condition might be better designated "Langerhans cell disease.".

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume61
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Histiocytosis
Maxilla
Mandible
Langerhans Cells
S100 Proteins
HLA-DR Antigens
Muramidase
Langerhans Cell Histiocytosis
Phagocytes
Immunoenzyme Techniques
Paraffin
Formaldehyde
Immune Sera
Neoplasms
Electrons
Staining and Labeling
Antigens

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Immunohistochemical study of idiopathic histiocytosis of the mandible and maxilla. / Stewart, Jeffery; Regezi, Joseph A.; Lloyd, Ricardo V.; McClatchey, Kenneth D.

In: Oral Surgery, Oral Medicine, Oral Pathology, Vol. 61, No. 1, 1986, p. 48-53.

Research output: Contribution to journalArticle

Stewart, Jeffery ; Regezi, Joseph A. ; Lloyd, Ricardo V. ; McClatchey, Kenneth D. / Immunohistochemical study of idiopathic histiocytosis of the mandible and maxilla. In: Oral Surgery, Oral Medicine, Oral Pathology. 1986 ; Vol. 61, No. 1. pp. 48-53.
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