Immunohistochemical studies on fibrillin in amyloidosis, lichen ruber planus and porphyria

K. Dahlback, Lynn Sakai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The pathogenesis of macular amyloidosis and lichen amyloidosis remains unsolved and the primary amyloid fibril protein(s) has not yet been identified. Ultrastructural association of skin amyloid with elastin associated microfibrils has been noted earlier. The presence of fibrillin in conjunction with such microfibrils was recently demonstrated immunohistochemically. The presence of fibrillin immunoreactivity in the amyloid deposits in skin biopsies from 3 patients with macular amyloidosis and 3 patients with lichen amyloidosis was studied, using monoclonal anti-fibrillin antibodies. For comparison, skin specimens were studied from five patients with lichen ruber planus, four patients with erythropoietic protoporphyria and from a patient with myeloma-associated cutaneous amyloidosis. Renal specimens from two cases of the amyloid A type of renal amyloidosis also were investigated. There was no immunostaining either of the keratin bodies in specimens of lichen ruber planus, the cutaneous PAS-positive vascular deposits in patients with erythropoietic protoporphyria, or the amyloid deposits in specimens of systemic amyloidosis and it was faint or absent in amyloid deposits in the specimens from patients with lichen amyloidosis. In contrast, distinct fibrillin immunoreactivity could be demonstrated in amyloid deposits in specimens from patients with macular amyloidosis. It was sometimes absent in deposits located in the upper part of the papillary dermis, close to the dermal epidermal junction zone, while consistently strong in deposits located lower down in the dermis. The results suggest that fibrillin or part of the fibrillin molecule may be present in some of the amyloid deposits in specimens of macular amyloidosis.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalActa Dermato-Venereologica
Volume70
Issue number4
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Porphyrias
Lichen Planus
Amyloidosis
Amyloid Plaques
Lichens
Skin
Erythropoietic Protoporphyria
Amyloid
Microfibrils
Dermis
Fibrillins
Amyloidogenic Proteins
Kidney
Elastin
Keratins
Blood Vessels
Anti-Idiotypic Antibodies
Monoclonal Antibodies
Biopsy

Keywords

  • Amyloidosis
  • Erythropoietic protoporphyria
  • Fibrillin
  • Lichen ruber planus

ASJC Scopus subject areas

  • Dermatology

Cite this

Immunohistochemical studies on fibrillin in amyloidosis, lichen ruber planus and porphyria. / Dahlback, K.; Sakai, Lynn.

In: Acta Dermato-Venereologica, Vol. 70, No. 4, 01.01.1990, p. 275-280.

Research output: Contribution to journalArticle

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