Immunohistochemical localization of the neuron-specific glucose transporter (GLUT3) to neuropil in adult rat brain

Anthony L. McCall, Antonia M. Van Bueren, Melissa Moholt-Siebert, Nicola J. Cherry, William R. Woodward

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

The precise histologic localization of GLUT3, a glucose transporter thought to be restricted to neurons, is unknown. Using a high-affinity, specific antiserum against rodent GLUT3 for immunocytochemistry, light microscopic staining concentrates heterogeneously in the neuropil in a region- and lamina-specific manner; intense staining characterizes areas with high rates of glucose utilization such as inferior colliculus and pyriform cortex. Neuropil localization with little perikaryal staining suggests that GLUT3 may provide the energy needed locally for synaptic transmission.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalBrain research
Volume659
Issue number1-2
DOIs
StatePublished - Oct 3 1994

Keywords

  • Brain metabolism
  • Energy metabolism
  • Glucose transporter
  • Immunocytochemistry
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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