Abstract
Children, especially neonates and young infants, are uniquely vulnerable to tuberculosis (TB) and frequently present with primary progressive pulmonary or disseminated disease. There is an urgent need to understand the unique immunobiology of Mycobacterium tuberculosis ( Mtb ) in young infants and to identify protective infant immune responses. The existing vaccine against TB, Mycobacterium bovis bacillus Calmette–Guérin ( M. bovis BCG), provides a partial protection against TB disease and disseminated forms of TB in infants; however, it is unknown how this partial protection is mediated. To end pediatric TB morbidity and mortality, a fully efficacious next-generation TB-vaccine is needed. Here, we focus on our current understanding of TB immunobiology as it pertains to young infants, and we evaluate what BCG-vaccination, as well as recently trialed novel TB-vaccines, has taught us about the immunobiology of mycobacterial infection in this population.
| Original language | English (US) |
|---|---|
| Journal | Journal of Pediatric Infectious Diseases |
| DOIs | |
| State | Accepted/In press - Apr 27 2017 |
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Keywords
- BCG
- immune response
- Immunity
- infant
- Mtb
- pediatric
- T cell
- tuberculosis
- vaccine
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Infectious Diseases
Cite this
Immunobiology of Pediatric Tuberculosis : Lessons Learned and Implications for an Improved TB-Vaccine. / Boer, Mardi C.; Lewinsohn, Deborah; Lancioni, Christina.
In: Journal of Pediatric Infectious Diseases, 27.04.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunobiology of Pediatric Tuberculosis
T2 - Lessons Learned and Implications for an Improved TB-Vaccine
AU - Boer, Mardi C.
AU - Lewinsohn, Deborah
AU - Lancioni, Christina
PY - 2017/4/27
Y1 - 2017/4/27
N2 - Children, especially neonates and young infants, are uniquely vulnerable to tuberculosis (TB) and frequently present with primary progressive pulmonary or disseminated disease. There is an urgent need to understand the unique immunobiology of Mycobacterium tuberculosis ( Mtb ) in young infants and to identify protective infant immune responses. The existing vaccine against TB, Mycobacterium bovis bacillus Calmette–Guérin ( M. bovis BCG), provides a partial protection against TB disease and disseminated forms of TB in infants; however, it is unknown how this partial protection is mediated. To end pediatric TB morbidity and mortality, a fully efficacious next-generation TB-vaccine is needed. Here, we focus on our current understanding of TB immunobiology as it pertains to young infants, and we evaluate what BCG-vaccination, as well as recently trialed novel TB-vaccines, has taught us about the immunobiology of mycobacterial infection in this population.
AB - Children, especially neonates and young infants, are uniquely vulnerable to tuberculosis (TB) and frequently present with primary progressive pulmonary or disseminated disease. There is an urgent need to understand the unique immunobiology of Mycobacterium tuberculosis ( Mtb ) in young infants and to identify protective infant immune responses. The existing vaccine against TB, Mycobacterium bovis bacillus Calmette–Guérin ( M. bovis BCG), provides a partial protection against TB disease and disseminated forms of TB in infants; however, it is unknown how this partial protection is mediated. To end pediatric TB morbidity and mortality, a fully efficacious next-generation TB-vaccine is needed. Here, we focus on our current understanding of TB immunobiology as it pertains to young infants, and we evaluate what BCG-vaccination, as well as recently trialed novel TB-vaccines, has taught us about the immunobiology of mycobacterial infection in this population.
KW - BCG
KW - immune response
KW - Immunity
KW - infant
KW - Mtb
KW - pediatric
KW - T cell
KW - tuberculosis
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=85031499115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031499115&partnerID=8YFLogxK
U2 - 10.1055/s-0037-1607233
DO - 10.1055/s-0037-1607233
M3 - Article
AN - SCOPUS:85031499115
JO - Journal of Pediatric Infectious Diseases
JF - Journal of Pediatric Infectious Diseases
SN - 1871-0336
ER -