Immunity and immunological memory following smallpox vaccination

Ian J. Amanna, Mark Slifka, Shane Crotty

    Research output: Contribution to journalArticle

    145 Citations (Scopus)

    Abstract

    The smallpox vaccine consists of live vaccinia virus and is generally considered the gold standard of vaccines, since it is the only one that has led to the complete eradication of an infectious disease from the human population. Renewed fears that smallpox might be deliberately released in an act of bioterrorism have led to resurgence in the study of immunity and immunological memory to vaccinia virus and other poxviruses. Here we review our current understanding of memory T-cell, memory B-cell, and antibody responses to vaccinia and related poxviruses, both in animal models and human subjects. Of particular interest are recent advances in understanding protective immunity to poxviruses, quantifying immunological memory to the smallpox vaccine in humans, and identifying major vaccinia-specific T-cell and B-cell epitopes. In addition, potential mechanisms for maintenance of immunological memory are discussed.

    Original languageEnglish (US)
    Pages (from-to)320-337
    Number of pages18
    JournalImmunological Reviews
    Volume211
    DOIs
    StatePublished - Jun 2006

    Fingerprint

    Immunologic Memory
    Poxviridae
    Smallpox
    Smallpox Vaccine
    Vaccinia
    Immunity
    Vaccination
    Vaccinia virus
    B-Lymphocyte Epitopes
    Bioterrorism
    T-Lymphocytes
    Fear
    Antibody Formation
    Communicable Diseases
    B-Lymphocytes
    Vaccines
    Animal Models
    Maintenance
    Population

    ASJC Scopus subject areas

    • Immunology

    Cite this

    Immunity and immunological memory following smallpox vaccination. / Amanna, Ian J.; Slifka, Mark; Crotty, Shane.

    In: Immunological Reviews, Vol. 211, 06.2006, p. 320-337.

    Research output: Contribution to journalArticle

    Amanna, Ian J. ; Slifka, Mark ; Crotty, Shane. / Immunity and immunological memory following smallpox vaccination. In: Immunological Reviews. 2006 ; Vol. 211. pp. 320-337.
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