TY - JOUR
T1 - Immune response to melanoma extracts in three melanoma-prone families
AU - Vandenbark, Arthur A.
AU - Greene, Mark H.
AU - Burger, Denis R.
AU - Mark Vetto, R.
AU - Reimer, Ronald R.
N1 - Funding Information:
1 Received October 27, 1978; accepted April 10, 1979. 2 Supported in part by Public Health Service contract NOICB53954 from the Division of Cancer Biology and Diagnosis, National Cancer Institute, and by Veterans Administration Project No. 648-9012. 3 Surgical Research Laboratory, Veterans Administration Medical Center, 3710 S.W. U.S. Veterans Hospital Rd., Portland, Oreg. 97207. 4 Department of Microbiology and Immunology, University of Oregon Health Sciences Center, Portland, Oreg. 97201. S Address reprint requests to Dr. Vandenbark at his first address. 6 Environmental Epidemiology Branch, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20205. 7 Department of Surgery, University of Oregon Health Sciences Center. 8 Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Cleveland, Ohio 44106.
PY - 1979/11
Y1 - 1979/11
N2 - Immune reactivity to melanoma extracts was measured by the leukocyte adherence Inhibition (LAI) test In 40 members of 3 melanoma-prone families. The melanoma patients had a wide range of responsiveness to the extract, the highest responder being a 10-year survivor. As a group, family members (Including spouses) without disease had significantly elevated LAI responses compared to those of unrelated controls (P<0.01). Within the families, members with close exposure to melanoma patients for 10 years or more had a significantly higher response to melanoma antigen than did members with 0-5 years of close exposure (P<0.05). Responses of spouses and members at high risk of developing melanoma (B-K mole syndrome) also correlated with length of exposure to patients, which suggests that the elevated LAI response was not genetically determined. The high frequency of positive responses to melanoma antigens In these families, particularly In spouses, suggests the presence of transmissible melanoma-associated material capable of Immunizing persons In contact with melanoma patients.
AB - Immune reactivity to melanoma extracts was measured by the leukocyte adherence Inhibition (LAI) test In 40 members of 3 melanoma-prone families. The melanoma patients had a wide range of responsiveness to the extract, the highest responder being a 10-year survivor. As a group, family members (Including spouses) without disease had significantly elevated LAI responses compared to those of unrelated controls (P<0.01). Within the families, members with close exposure to melanoma patients for 10 years or more had a significantly higher response to melanoma antigen than did members with 0-5 years of close exposure (P<0.05). Responses of spouses and members at high risk of developing melanoma (B-K mole syndrome) also correlated with length of exposure to patients, which suggests that the elevated LAI response was not genetically determined. The high frequency of positive responses to melanoma antigens In these families, particularly In spouses, suggests the presence of transmissible melanoma-associated material capable of Immunizing persons In contact with melanoma patients.
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U2 - 10.1093/jnci/63.5.1147
DO - 10.1093/jnci/63.5.1147
M3 - Article
C2 - 291746
AN - SCOPUS:0018579347
SN - 0027-8874
VL - 63
SP - 1147
EP - 1151
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 5
ER -