Immune response of lymphocytes from patients with multiple sclerosis to phytohemagglutinin, basic protein of myelin and measles antigens

Halina Offner, T. Ammitzboll, J. Clausen, T. Fog, K. Hyllested, E. Einstein

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The effect of phytohemagglutinin (PHA), basic protein (BP) and various measles antigens was studied in vitro on 'whole blood cultures' from multiple sclerosis (MS) patients and controls. Lymphocytes from both MS patients and controls did not transform in vitro in the presence of basic protein and measles antigens. Quantitative studies with a liquid scintillation technique after incorporation of tritiated thymidine showed impaired lymphocyte transformation with PHA in 9 out of 26 MS patients. There was a correlation between duration of the disease and transformation of lymphocytes form MS patients.

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalActa Neurologica Scandinavica
Volume50
Issue number3
StatePublished - 1974
Externally publishedYes

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Myelin Basic Protein
Measles
Phytohemagglutinins
Multiple Sclerosis
Lymphocytes
Antigens
Lymphocyte Activation
Thymidine
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Immune response of lymphocytes from patients with multiple sclerosis to phytohemagglutinin, basic protein of myelin and measles antigens. / Offner, Halina; Ammitzboll, T.; Clausen, J.; Fog, T.; Hyllested, K.; Einstein, E.

In: Acta Neurologica Scandinavica, Vol. 50, No. 3, 1974, p. 373-381.

Research output: Contribution to journalArticle

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