Immune recognition of irradiated cancer cells

Erik Wennerberg, Claire Vanpouille-Box, Sophia Bornstein, Takahiro Yamazaki, Sandra Demaria, Lorenzo Galluzzi

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Ionizing irradiation has been extensively employed for the clinical management of solid tumors, with therapeutic or palliative intents, for decades. Until recently, radiation therapy (RT) was believed to mediate antineoplastic activity mostly (if not only) as a consequence of cancer cell-intrinsic effects. Indeed, the macromolecular damage imposed to malignant cells by RT initiates one or multiple signal transduction cascades that drive a permanent proliferative arrest (cellular senescence) or regulated cell death. Both these phenomena show a rather linear dose-response correlation. However, RT also mediates consistent immunological activity, not only as an “on-target effect” originating within irradiated cancer cells, but also as an “off-target effect” depending on the interaction between RT and stromal, endothelial, and immune components of the tumor microenvironment. Interestingly, the immunological activity of RT does not exhibit linear dose-response correlation. Here, we discuss the mechanisms whereby RT alters the capacity of the immune system to recognize and eliminate irradiated cancer cells, either as an “on-target” or as on “off-target” effect. In particular, we discuss the antagonism between the immunostimulatory and immunosuppressive effects of RT as we delineate combinatorial strategies to boost the former at the expenses of the latter.

Original languageEnglish (US)
Pages (from-to)220-230
Number of pages11
JournalImmunological Reviews
Volume280
Issue number1
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Fingerprint

Radiotherapy
Neoplasms
Tumor Microenvironment
Cell Aging
Immunosuppressive Agents
Cell- and Tissue-Based Therapy
Antineoplastic Agents
Immune System
Signal Transduction
Cell Death

Keywords

  • autophagy
  • danger signaling
  • immunogenic cell death
  • mutational load
  • NKG2D
  • tumor neoantigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Wennerberg, E., Vanpouille-Box, C., Bornstein, S., Yamazaki, T., Demaria, S., & Galluzzi, L. (2017). Immune recognition of irradiated cancer cells. Immunological Reviews, 280(1), 220-230. https://doi.org/10.1111/imr.12568

Immune recognition of irradiated cancer cells. / Wennerberg, Erik; Vanpouille-Box, Claire; Bornstein, Sophia; Yamazaki, Takahiro; Demaria, Sandra; Galluzzi, Lorenzo.

In: Immunological Reviews, Vol. 280, No. 1, 01.11.2017, p. 220-230.

Research output: Contribution to journalReview article

Wennerberg, E, Vanpouille-Box, C, Bornstein, S, Yamazaki, T, Demaria, S & Galluzzi, L 2017, 'Immune recognition of irradiated cancer cells', Immunological Reviews, vol. 280, no. 1, pp. 220-230. https://doi.org/10.1111/imr.12568
Wennerberg E, Vanpouille-Box C, Bornstein S, Yamazaki T, Demaria S, Galluzzi L. Immune recognition of irradiated cancer cells. Immunological Reviews. 2017 Nov 1;280(1):220-230. https://doi.org/10.1111/imr.12568
Wennerberg, Erik ; Vanpouille-Box, Claire ; Bornstein, Sophia ; Yamazaki, Takahiro ; Demaria, Sandra ; Galluzzi, Lorenzo. / Immune recognition of irradiated cancer cells. In: Immunological Reviews. 2017 ; Vol. 280, No. 1. pp. 220-230.
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