Immune enhancement of skin carcinogenesis by CD4+ T cells

Dylan Daniel, Nicole Meyer-Morse, Emily K. Bergsland, Kerstin Dehne, Lisa Coussens, Douglas Hanahan

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

In a transgenic model of multi-stage squamous carcinogenesis induced by human papillomavirus (HPV) oncogenes, infiltrating CD4+ T cells can be detected in both premalignant and malignant lesions. The lymph nodes that drain sites of epidermal neoplasia contain activated CD4+ T cells predominantly reactive toward Staphylococcal bacterial antigens. HPV16 mice deficient in CD4+ T cells were found to have delayed neoplastic progression and a lower incidence of tumors. This delay in carcinogenesis is marked by decreased infiltration of neutrophils, and reduced activity of matrix metalloproteinase-9, an important cofactor for tumor progression in this model. The data reveal an unexpected capability of CD4 T cells, whereby, proinflammatory CD4+ T cells, apparently responding to bacterial infection of dysplastic skin lesions, can inadvertently enhance neoplastic progression to invasive cancer.

Original languageEnglish (US)
Pages (from-to)1017-1028
Number of pages12
JournalJournal of Experimental Medicine
Volume197
Issue number8
DOIs
StatePublished - Apr 21 2003
Externally publishedYes

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Carcinogenesis
T-Lymphocytes
Skin
Neoplasms
Bacterial Antigens
Neutrophil Infiltration
Matrix Metalloproteinase 9
Oncogenes
Bacterial Infections
Lymph Nodes
Incidence

Keywords

  • Cancer
  • Inflammation
  • Lymphocyte
  • Mice
  • Transgenic

ASJC Scopus subject areas

  • Immunology

Cite this

Daniel, D., Meyer-Morse, N., Bergsland, E. K., Dehne, K., Coussens, L., & Hanahan, D. (2003). Immune enhancement of skin carcinogenesis by CD4+ T cells. Journal of Experimental Medicine, 197(8), 1017-1028. https://doi.org/10.1084/jem.20021047

Immune enhancement of skin carcinogenesis by CD4+ T cells. / Daniel, Dylan; Meyer-Morse, Nicole; Bergsland, Emily K.; Dehne, Kerstin; Coussens, Lisa; Hanahan, Douglas.

In: Journal of Experimental Medicine, Vol. 197, No. 8, 21.04.2003, p. 1017-1028.

Research output: Contribution to journalArticle

Daniel, D, Meyer-Morse, N, Bergsland, EK, Dehne, K, Coussens, L & Hanahan, D 2003, 'Immune enhancement of skin carcinogenesis by CD4+ T cells', Journal of Experimental Medicine, vol. 197, no. 8, pp. 1017-1028. https://doi.org/10.1084/jem.20021047
Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens L, Hanahan D. Immune enhancement of skin carcinogenesis by CD4+ T cells. Journal of Experimental Medicine. 2003 Apr 21;197(8):1017-1028. https://doi.org/10.1084/jem.20021047
Daniel, Dylan ; Meyer-Morse, Nicole ; Bergsland, Emily K. ; Dehne, Kerstin ; Coussens, Lisa ; Hanahan, Douglas. / Immune enhancement of skin carcinogenesis by CD4+ T cells. In: Journal of Experimental Medicine. 2003 ; Vol. 197, No. 8. pp. 1017-1028.
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