Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis

Sanjay V. Malhotra, Vineet Kumar, Christian Velez, Beatriz Zayas

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A study of the effects of imidazolium-based ionic liquids on 60 human cancer cell lines representing diverse histologies has identified four compounds which show potency at a nanomolar dose. Their effects on annexin V, DNA fragmentation, and the cell cycle, together with mitochondrial membrane permeabilization tests, provide insights into their mechanism of action. Also, experiments with A431 human epidermoid carcinoma cells suggest the activation of an apoptotic pathway, due to activity of the initiator caspase 8 and effector caspase 3.

Original languageEnglish (US)
Pages (from-to)1404-1409
Number of pages6
JournalMedChemComm
Volume5
Issue number9
DOIs
StatePublished - Sep 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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