Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography

Niloy Choudhury, Yaguang Zeng, Anders Fridberger, Fangyi Chen, Dingjun Zha, Alfred Nuttall, Ruikang K. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Studying the sound stimulated vibrations of various membranes that form the complex structure of the organ of Corti in the cochlea of the inner ear is essential for understanding how the travelling sound wave of the basilar membrane couples its energy to the organ structures. In this paper we report the feasibility of using phase-sensitive Fourier domain optical coherence tomography (FD-OCT) to image the vibration of various micro-structures of the cochlea at the same time. An excised cochlea of a guinea pig was stimulated using sounds at various frequencies and vibration image was obtained. When measuring the apex area, vibration signal from different turns, which have different best response frequencies are obtained in the same image. The method has the potential to measure the response from a much wider region of the cochlea than any other currently used method. The noise floor for vibration image for the system at 200 Hz was ~0.3nm.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7889
DOIs
StatePublished - 2011
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Fingerprint

guinea pigs
cochlea
Optical tomography
Cochlea
Optical Coherence Tomography
Vibration
partitions
Guinea Pigs
tomography
Acoustic waves
Imaging techniques
vibration
Vibrations (mechanical)
Membranes
organs
Frequency response
Basilar Membrane
membranes
Organ of Corti
acoustics

Keywords

  • biomedical optical imaging
  • cochlear vibration
  • image processing
  • Optical coherence tomography
  • optical interferometry
  • phase-sensitive Fourier domain OCT
  • spectral interferometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Choudhury, N., Zeng, Y., Fridberger, A., Chen, F., Zha, D., Nuttall, A., & Wang, R. K. (2011). Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7889). [788930] https://doi.org/10.1117/12.875534

Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography. / Choudhury, Niloy; Zeng, Yaguang; Fridberger, Anders; Chen, Fangyi; Zha, Dingjun; Nuttall, Alfred; Wang, Ruikang K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889 2011. 788930.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Choudhury, N, Zeng, Y, Fridberger, A, Chen, F, Zha, D, Nuttall, A & Wang, RK 2011, Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7889, 788930, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, San Francisco, CA, United States, 1/24/11. https://doi.org/10.1117/12.875534
Choudhury N, Zeng Y, Fridberger A, Chen F, Zha D, Nuttall A et al. Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889. 2011. 788930 https://doi.org/10.1117/12.875534
Choudhury, Niloy ; Zeng, Yaguang ; Fridberger, Anders ; Chen, Fangyi ; Zha, Dingjun ; Nuttall, Alfred ; Wang, Ruikang K. / Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7889 2011.
@inproceedings{1455f395b11d4fd99f5bb45f7666a702,
title = "Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography",
abstract = "Studying the sound stimulated vibrations of various membranes that form the complex structure of the organ of Corti in the cochlea of the inner ear is essential for understanding how the travelling sound wave of the basilar membrane couples its energy to the organ structures. In this paper we report the feasibility of using phase-sensitive Fourier domain optical coherence tomography (FD-OCT) to image the vibration of various micro-structures of the cochlea at the same time. An excised cochlea of a guinea pig was stimulated using sounds at various frequencies and vibration image was obtained. When measuring the apex area, vibration signal from different turns, which have different best response frequencies are obtained in the same image. The method has the potential to measure the response from a much wider region of the cochlea than any other currently used method. The noise floor for vibration image for the system at 200 Hz was ~0.3nm.",
keywords = "biomedical optical imaging, cochlear vibration, image processing, Optical coherence tomography, optical interferometry, phase-sensitive Fourier domain OCT, spectral interferometry",
author = "Niloy Choudhury and Yaguang Zeng and Anders Fridberger and Fangyi Chen and Dingjun Zha and Alfred Nuttall and Wang, {Ruikang K.}",
year = "2011",
doi = "10.1117/12.875534",
language = "English (US)",
isbn = "9780819484260",
volume = "7889",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography

AU - Choudhury, Niloy

AU - Zeng, Yaguang

AU - Fridberger, Anders

AU - Chen, Fangyi

AU - Zha, Dingjun

AU - Nuttall, Alfred

AU - Wang, Ruikang K.

PY - 2011

Y1 - 2011

N2 - Studying the sound stimulated vibrations of various membranes that form the complex structure of the organ of Corti in the cochlea of the inner ear is essential for understanding how the travelling sound wave of the basilar membrane couples its energy to the organ structures. In this paper we report the feasibility of using phase-sensitive Fourier domain optical coherence tomography (FD-OCT) to image the vibration of various micro-structures of the cochlea at the same time. An excised cochlea of a guinea pig was stimulated using sounds at various frequencies and vibration image was obtained. When measuring the apex area, vibration signal from different turns, which have different best response frequencies are obtained in the same image. The method has the potential to measure the response from a much wider region of the cochlea than any other currently used method. The noise floor for vibration image for the system at 200 Hz was ~0.3nm.

AB - Studying the sound stimulated vibrations of various membranes that form the complex structure of the organ of Corti in the cochlea of the inner ear is essential for understanding how the travelling sound wave of the basilar membrane couples its energy to the organ structures. In this paper we report the feasibility of using phase-sensitive Fourier domain optical coherence tomography (FD-OCT) to image the vibration of various micro-structures of the cochlea at the same time. An excised cochlea of a guinea pig was stimulated using sounds at various frequencies and vibration image was obtained. When measuring the apex area, vibration signal from different turns, which have different best response frequencies are obtained in the same image. The method has the potential to measure the response from a much wider region of the cochlea than any other currently used method. The noise floor for vibration image for the system at 200 Hz was ~0.3nm.

KW - biomedical optical imaging

KW - cochlear vibration

KW - image processing

KW - Optical coherence tomography

KW - optical interferometry

KW - phase-sensitive Fourier domain OCT

KW - spectral interferometry

UR - http://www.scopus.com/inward/record.url?scp=79953740104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953740104&partnerID=8YFLogxK

U2 - 10.1117/12.875534

DO - 10.1117/12.875534

M3 - Conference contribution

AN - SCOPUS:79953740104

SN - 9780819484260

VL - 7889

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -