Imaging subcortical auditory activity in humans

Alexander Guimaraes, J. R. Melcher, T. M. Talavage, J. R. Baker, P. Ledden, B. R. Rosen, N. Y S Kiang, B. C. Fullerton, R. M. Weisskoff

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalHuman Brain Mapping
Volume6
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Human Activities
Brain Stem
Auditory Cortex
Magnetic Resonance Imaging
Auditory Pathways
Inferior Colliculi
Pulsatile Flow
Neuroimaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Guimaraes, A., Melcher, J. R., Talavage, T. M., Baker, J. R., Ledden, P., Rosen, B. R., ... Weisskoff, R. M. (1998). Imaging subcortical auditory activity in humans. Human Brain Mapping, 6(1), 33-41. https://doi.org/10.1002/(SICI)1097-0193(1998)6:1<33::AID-HBM3>3.0.CO;2-M

Imaging subcortical auditory activity in humans. / Guimaraes, Alexander; Melcher, J. R.; Talavage, T. M.; Baker, J. R.; Ledden, P.; Rosen, B. R.; Kiang, N. Y S; Fullerton, B. C.; Weisskoff, R. M.

In: Human Brain Mapping, Vol. 6, No. 1, 1998, p. 33-41.

Research output: Contribution to journalArticle

Guimaraes, A, Melcher, JR, Talavage, TM, Baker, JR, Ledden, P, Rosen, BR, Kiang, NYS, Fullerton, BC & Weisskoff, RM 1998, 'Imaging subcortical auditory activity in humans', Human Brain Mapping, vol. 6, no. 1, pp. 33-41. https://doi.org/10.1002/(SICI)1097-0193(1998)6:1<33::AID-HBM3>3.0.CO;2-M
Guimaraes, Alexander ; Melcher, J. R. ; Talavage, T. M. ; Baker, J. R. ; Ledden, P. ; Rosen, B. R. ; Kiang, N. Y S ; Fullerton, B. C. ; Weisskoff, R. M. / Imaging subcortical auditory activity in humans. In: Human Brain Mapping. 1998 ; Vol. 6, No. 1. pp. 33-41.
@article{4ac4856e81a34aa7a61594297bd976bb,
title = "Imaging subcortical auditory activity in humans",
abstract = "There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans.",
author = "Alexander Guimaraes and Melcher, {J. R.} and Talavage, {T. M.} and Baker, {J. R.} and P. Ledden and Rosen, {B. R.} and Kiang, {N. Y S} and Fullerton, {B. C.} and Weisskoff, {R. M.}",
year = "1998",
doi = "10.1002/(SICI)1097-0193(1998)6:1<33::AID-HBM3>3.0.CO;2-M",
language = "English (US)",
volume = "6",
pages = "33--41",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Imaging subcortical auditory activity in humans

AU - Guimaraes, Alexander

AU - Melcher, J. R.

AU - Talavage, T. M.

AU - Baker, J. R.

AU - Ledden, P.

AU - Rosen, B. R.

AU - Kiang, N. Y S

AU - Fullerton, B. C.

AU - Weisskoff, R. M.

PY - 1998

Y1 - 1998

N2 - There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans.

AB - There is a lack of physiological data pertaining to how listening humans process auditory information. Functional magnetic resonance imaging (fMRI) has provided some data for the auditory cortex in awake humans, but there is still a paucity of comparable data for subcortical auditory areas where the early stages of processing take place, as amply demonstrated by single-unit studies in animals. It is unclear why fMRI has been unsuccessful in imaging auditory brain-stem activity, but one problem may be cardiac-related, pulsatile brain-stem motion. To examine this, a method eliminating such motion (using cardiac gating) was applied to map sound-related activity in the auditory cortices and inferior colliculi in the brain stem. Activation in both the colliculi and cortex became more discernible when gating was used. In contrast with the cortex, the improvement in the colliculi resulted from a reduction in signal variability, rather than from an increase in percent signal change. This reduction is consistent with the hypothesis that motion or pulsatile flow is a major factor in brain-stem imaging. The way now seems clear to studying activity throughout the human auditory pathway in listening humans.

UR - http://www.scopus.com/inward/record.url?scp=0031952566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031952566&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0193(1998)6:1<33::AID-HBM3>3.0.CO;2-M

DO - 10.1002/(SICI)1097-0193(1998)6:1<33::AID-HBM3>3.0.CO;2-M

M3 - Article

C2 - 9673661

AN - SCOPUS:0031952566

VL - 6

SP - 33

EP - 41

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 1

ER -