Imaging oxygenation of human tumours

Anwar R. Padhani, Kenneth A. Krohn, Jason S. Lewis, Markus Alber

Research output: Contribution to journalReview article

243 Scopus citations

Abstract

Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and invasive techniques but the inter-relationships between these remains largely undefined. 18F-MISO and Cu-ATSM-PET, and BOLD-MRI are the lead contenders for human application based on their non-invasive nature, ease of use and robustness, measurement of hypoxia status, validity, ability to demonstrate heterogeneity and general availability, these techniques are the primary focus of this review. We discuss where developments are required for hypoxia imaging to become clinically useful and explore potential new uses for hypoxia imaging techniques including biological conformal radiotherapy.

Original languageEnglish (US)
Pages (from-to)861-872
Number of pages12
JournalEuropean Radiology
Volume17
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • BOLD-MRI
  • Cancer
  • Cu-ATSM-PET
  • F-MISO-PET
  • Hypoxia
  • Radiotherapy
  • Tumour Resistance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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