Imaging organ of Corti vibration using Fourier-domain OCT

Niloy Choudhury, Fangyi Chen, Anders Fridberger, Dingjun Zha, Steven L. Jacques, Ruikang K. Wang, Alfred L. Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Measuring the sound stimulated vibration from various structures in the organ of Corti is important in understanding how the small vibrations are amplified and detected. In this study we examine the feasibility of using phase-sensitive Fourier domain optical coherence tomography (PSFD-OCT) to measure vibration of the cellular structures of the organ of Corti. PSFD-OCT is a low coherence interferrometry system where the interferrogram is detected as a function of wavelength. The phase of the Fourier transformation of the detected spectra contains path deference (between the sample arm and the reference arm) information of the interferometer. In PSFD-OCT this phase is measured as a function of time and thus any time dependent change in the path difference between the sample arm and the reference arm can be detected. In the experiment, we used an in vitro preparation of the guinea pig cochlea and made a surgical opening at the apical end to access the organ of Corti. By applying tones with different frequencies via the intact middle ear, we recorded the structural vibration inside the organ of Corti. Vibration amplitude and phase of different substructures were mapped on a cross-section view of the organ of Corti. Although the measurements were made at the apical turn of the cochlea, it will be possible to make vibration measurement from various turns of the cochlea. The noise floor of the system was 0.3 nm, calibrated using a piezo stack as a calibrator.

Original languageEnglish (US)
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages391-395
Number of pages5
DOIs
StatePublished - Dec 12 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Publication series

NameAIP Conference Proceedings
Volume1403
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

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Keywords

  • cochlear vibration
  • low coherence interferometry
  • optical coherence tomography
  • phase-sensitive Fourier-domain OCT

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Choudhury, N., Chen, F., Fridberger, A., Zha, D., Jacques, S. L., Wang, R. K., & Nuttall, A. L. (2011). Imaging organ of Corti vibration using Fourier-domain OCT. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (pp. 391-395). (AIP Conference Proceedings; Vol. 1403). https://doi.org/10.1063/1.3658117