TY - GEN
T1 - Imaging optically induced neural activity in the brain
AU - Mahadevan-Jansen, Anita
AU - Cayce, Jonathan M.
AU - Friedman, Robert
AU - Roe, Anna W.
AU - Konrad, Peter E.
AU - Hillman, Elizabeth
AU - Jansen, E. Duco
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new setof challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study presents ourfirst attempt to translate INS to in vivo stimulation of the CNSand to image the related response. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.
AB - Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new setof challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS. This study presents ourfirst attempt to translate INS to in vivo stimulation of the CNSand to image the related response. The results from this study show that INS generates intrinsic optical signals of similar magnitude and shape associated with well characterized mechanical stimuli. The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural prosthetics.
UR - http://www.scopus.com/inward/record.url?scp=78650802692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650802692&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5627920
DO - 10.1109/IEMBS.2010.5627920
M3 - Conference contribution
C2 - 21097240
AN - SCOPUS:78650802692
SN - 9781424441235
T3 - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
SP - 3379
EP - 3381
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -