Imaging in biological tissues by means of diffraction tomography with photon density waves

Andreas H. Hielscher, Frank K. Tittel, Steven L. Jacques

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


In biological tissues it is possible to generate photon density waves with wavelength below 5 cm. When these kind of waves encounter optical inhomogeneities with diameters in the mm- and cm-range, typical scattering effects occur. These scattering effect can be compared to the well known effect of ultrasound scattering. Ultrasound gets scattered at regions with different compressibility and density, while photon density waves are scattered at regions with different absorption and scattering coefficient. In this study, analytical solutions for the time dependent photon diffusion equation are used to estimate photon density wave diffraction effects caused by spherical optical inhomogeneities. The detectability of tumors and hemorrhages in the brain, based on the diffraction pattern generated by these heterogeneities, is discussed in detail.

Original languageEnglish (US)
Pages (from-to)75-85
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 31 1995
EventPhoton Transport in Highly Scattering Tissue 1994 - Lille, France
Duration: Sep 6 1994Sep 10 1994

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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