Imaging for Regenerative Therapy for PAD

C. M. Kramer, M. Yadava, Jonathan Lindner

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Angiographic techniques are excellent at assessing patency and status of the larger arteries within the lower extremity in patients with peripheral artery disease (PAD), but are not quantitative and are unable to assess smaller vessels, including collaterals, or perfusion at the tissue level. The ability to image smaller vessels and measure tissue perfusion are an unmet clinical need in the evaluation of patients with PAD who are candidates for regeneration therapy with stem cells or other angiogenic therapies. Potential improvements with these therapies are more likely to be at the microvascular level, which cannot be assessed by traditional angiography. In this regard, newer techniques such as magnetic resonance imaging (MRI) perfusion imaging, positron emission tomography (PET), and contrast-enhanced ultrasound (CEU) are in various stages of development for this important use.

    Original languageEnglish (US)
    Title of host publicationRegenerative Medicine for Peripheral Artery Disease
    PublisherElsevier Inc.
    Pages95-116
    Number of pages22
    ISBN (Print)9780128013441
    DOIs
    StatePublished - Jun 13 2016

    Keywords

    • Contrast-enhanced ultrasound
    • Magnetic resonance imaging
    • Perfusion
    • Peripheral arterial disease
    • Positron emission tomography

    ASJC Scopus subject areas

    • Engineering(all)
    • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kramer, C. M., Yadava, M., & Lindner, J. (2016). Imaging for Regenerative Therapy for PAD. In Regenerative Medicine for Peripheral Artery Disease (pp. 95-116). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801344-1.00007-3