Imaging Epigenetics of Prenatal THC

Nicole R. Zürcher, Victoria H.J. Roberts, Matthias C. Schabel, Andrea G. Edlow, Jacob M. Hooker, Jamie O. Lo

Research output: Contribution to journalReview articlepeer-review

Abstract

Prenatal exposure to marijuana may lead to epigenetic alterations in the placenta and fetal brain, affecting short- and long-term offspring health. This Viewpoint addresses the critical need to study and characterize the impact of maternal marijuana use and consequences of in utero exposure on later development and health. We highlight the development of new PET imaging tools and the opportunity for longitudinal in vivo non-human primate studies to help elucidate epigenetic changes resulting from prenatal marijuana exposure throughout gestation.

Original languageEnglish (US)
Pages (from-to)1466-1468
Number of pages3
JournalACS Chemical Neuroscience
Volume12
Issue number9
DOIs
StatePublished - May 5 2021

Keywords

  • Epigenetics
  • THC
  • delta-9-tetrahydrocannabinol
  • histone deacetylase
  • marijuana
  • positron emission tomography
  • pregnancy

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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