Imaging endogenous dopamine competition with [11C]raclopride in the human brain

N. D. Volkow, G. J. Wang, J. S. Fowler, J. Logan, D. Schlyer, Robert Hitzemann, J. Lieberman, B. Angrist, N. Pappas, R. MacGregor, G. Burr, T. Cooper, A. P. Wolf

Research output: Contribution to journalArticle

320 Citations (Scopus)

Abstract

This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [11C]raclopride, a D2 receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [11C]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate-induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalSynapse
Volume16
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Raclopride
Methylphenidate
Dopamine
Brain
Corpus Striatum
Brain Diseases
Positron-Emission Tomography
Anxiety
Pharmaceutical Preparations

Keywords

  • [C]-Raclopride
  • Methylphenidate
  • Positron emission tomography
  • Receptors
  • Synapse

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Pharmacology

Cite this

Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., ... Wolf, A. P. (1994). Imaging endogenous dopamine competition with [11C]raclopride in the human brain. Synapse, 16(4), 255-262.

Imaging endogenous dopamine competition with [11C]raclopride in the human brain. / Volkow, N. D.; Wang, G. J.; Fowler, J. S.; Logan, J.; Schlyer, D.; Hitzemann, Robert; Lieberman, J.; Angrist, B.; Pappas, N.; MacGregor, R.; Burr, G.; Cooper, T.; Wolf, A. P.

In: Synapse, Vol. 16, No. 4, 1994, p. 255-262.

Research output: Contribution to journalArticle

Volkow, ND, Wang, GJ, Fowler, JS, Logan, J, Schlyer, D, Hitzemann, R, Lieberman, J, Angrist, B, Pappas, N, MacGregor, R, Burr, G, Cooper, T & Wolf, AP 1994, 'Imaging endogenous dopamine competition with [11C]raclopride in the human brain', Synapse, vol. 16, no. 4, pp. 255-262.
Volkow ND, Wang GJ, Fowler JS, Logan J, Schlyer D, Hitzemann R et al. Imaging endogenous dopamine competition with [11C]raclopride in the human brain. Synapse. 1994;16(4):255-262.
Volkow, N. D. ; Wang, G. J. ; Fowler, J. S. ; Logan, J. ; Schlyer, D. ; Hitzemann, Robert ; Lieberman, J. ; Angrist, B. ; Pappas, N. ; MacGregor, R. ; Burr, G. ; Cooper, T. ; Wolf, A. P. / Imaging endogenous dopamine competition with [11C]raclopride in the human brain. In: Synapse. 1994 ; Vol. 16, No. 4. pp. 255-262.
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