Imaging Cognitive Decline in Aging: Predicting Decline with Structural Imaging

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The focus of this chapter is predicting cognitive decline or dementia in normal older people using structural imaging. Key questions addressed include the following: What are the major methods, both clinical and imaging, that may help us to predict decline? What underlying pathologies do structural changes preceding decline suggest are developing in the brain? What is the evidence from structural studies that anatomical changes are present before behavioral ones or precede the diagnosis of mild cognitive impairment or dementia? Does imaging provide information about the pace of future decline? What are the limitations of these studies? Finally, what are the implications of structural imaging outcomes for application to the conduct of treatment studies and future research?

Original languageEnglish (US)
Title of host publicationImaging the Aging Brain
PublisherOxford University Press
ISBN (Electronic)9780199864836
ISBN (Print)9780195328875
DOIs
StatePublished - Feb 1 2010

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Keywords

  • Aging
  • Clinical prediction
  • Cognition
  • Dementia
  • MRI
  • Mild cognitive impairment
  • Neuropathology
  • Normal brain aging
  • Structural imaging

ASJC Scopus subject areas

  • Neuroscience(all)

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