I'm listening, I'm listening: Fatal forty DDI: Diltiazem, carbamazepine, CYP3A4

Catherine Marcucci; Jerusha Taylor; Ansgar Brambrink; Neil B. Sandson

doi:10.1007/978-1-4614-7495-1_135

I'm listening, I'm listening: Fatal forty DDI: Diltiazem, carbamazepine, CYP3A4

Catherine Marcucci, Jerusha Taylor, Ansgar Brambrink, Neil B. Sandson

Anesthesiology & Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses a complex pharmacokinetic interaction between carbamazepine and diltiazem, resulting in carbamazepine toxicity and decreased effi- cacy of diltiazem. Carbamazepine is both a cytochrome P450 3A4 substrate and inducer and diltiazem is a 3A4 inhibitor and substrate.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	611-614
Number of pages	4
ISBN (Print)	9781461474951, 9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_135
State	Published - Sep 15 2015

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-7495-1_135

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abstract = "This case discusses a complex pharmacokinetic interaction between carbamazepine and diltiazem, resulting in carbamazepine toxicity and decreased effi- cacy of diltiazem. Carbamazepine is both a cytochrome P450 3A4 substrate and inducer and diltiazem is a 3A4 inhibitor and substrate.",

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I'm listening, I'm listening: Fatal forty DDI: Diltiazem, carbamazepine, CYP3A4

Abstract

ASJC Scopus subject areas

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