Illuminating the oral microbiome and its host interactions: tools and approaches for molecular ecological studies

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5 Scopus citations

Abstract

A more comprehensive understanding of oral diseases like caries and periodontitis is dependent on an intimate understanding of the microbial ecological processes that are responsible for disease development. With this review, we provide a comprehensive overview of relevant molecular ecology techniques that have played critical roles in the current understanding of human oral biofilm development, interspecies interactions, and microbiome biogeography. The primary focus is on relevant technologies and examples available in the oral microbiology literature. However, most, if not all, of the described technologies should be readily adaptable for studies of microbiomes from other mucosal sites in the body. Therefore, this review is intended to serve as a reference guide used by microbiome researchers as they inevitably transition into molecular mechanistic studies of the many significant phenotypes observed clinically.

Original languageEnglish (US)
Article numberfuac052
JournalFEMS Microbiology Reviews
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2023

Keywords

  • microbial ecology
  • microbial genetics
  • microbiome
  • oral biofilm

ASJC Scopus subject areas

  • General Medicine

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