Ileal absorption was studied in male Wistar rats 6 weeks after resection of all small bowel distal to the ligament of Treitz except for 20 cm of ileum. Intestinal absorption of 3-O-methylglucose (3-O-MG) and 1-aminocyclopentanecarboxylic acid (ACPC) was measured by in vivo perfusion and an in vitro ring technique. These substrates are actively transported but are not metabolized by the cell, so cellular degradation or utilization cannot influence the rate of uptake. Following resection, ileal mucosal cells took up less ACPC than unresected controls. There were no differences in cellular uptake of 3-O-MG, but active uptake of this compound was minimal. The decrease in active uptake of ACPC probably reflected immaturity of the proliferating mucosal cells in the adapting ileal remnant after proximal resection.
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