IL6 and IL1B polymorphisms are associated with fat mass in older men: The MrOS study Sweden

Louise Strandberg, Dan Mellström, Östen Ljunggren, Elin Grundberg, Magnus K. Karlsson, Anna H. Holmberg, Eric Orwoll, Anna L. Eriksson, Johan Svedberg, Magnus Bengtsson, Claes Ohlsson, John Olov Jansson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n 3,014). The study subjects were from the Swedish part of the MrOS multicenter population study and 69-81 years of age. The IL6 174 G>C (Minor allele frequency (MAF) 48) gene promoter polymorphism was associated with the primary outcome total fat mass (P 0.006) and regional fat masses, but not with lean body mass. The IL1B 31T>C (MAF 34) polymorphism was also associated with total fat (P 0.007) and regional fat masses, but not lean body mass. The IL-1 receptor antagonist (IL-1ra) gene (IL1RN) 2018 T>C (MAF 27) polymorphism (in linkage disequilibrium (LD) with a well-studied variable number tandem repeat of 86 base pair (bp)) and IL1B 3953 C>T (MAF 26) polymorphism were not associated with total fat mass. In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalObesity
Volume16
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

Sweden
Interleukin-6
Fats
Gene Frequency
Interleukin-1
Obesity
Genes
Minisatellite Repeats
Interleukin-1 Receptors
Linkage Disequilibrium
Photon Absorptiometry
Knockout Mice
Base Pairing
Multicenter Studies
Adipose Tissue
Population

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Strandberg, L., Mellström, D., Ljunggren, Ö., Grundberg, E., Karlsson, M. K., Holmberg, A. H., ... Jansson, J. O. (2008). IL6 and IL1B polymorphisms are associated with fat mass in older men: The MrOS study Sweden. Obesity, 16(3), 710-713. https://doi.org/10.1038/oby.2007.95

IL6 and IL1B polymorphisms are associated with fat mass in older men : The MrOS study Sweden. / Strandberg, Louise; Mellström, Dan; Ljunggren, Östen; Grundberg, Elin; Karlsson, Magnus K.; Holmberg, Anna H.; Orwoll, Eric; Eriksson, Anna L.; Svedberg, Johan; Bengtsson, Magnus; Ohlsson, Claes; Jansson, John Olov.

In: Obesity, Vol. 16, No. 3, 03.2008, p. 710-713.

Research output: Contribution to journalArticle

Strandberg, L, Mellström, D, Ljunggren, Ö, Grundberg, E, Karlsson, MK, Holmberg, AH, Orwoll, E, Eriksson, AL, Svedberg, J, Bengtsson, M, Ohlsson, C & Jansson, JO 2008, 'IL6 and IL1B polymorphisms are associated with fat mass in older men: The MrOS study Sweden', Obesity, vol. 16, no. 3, pp. 710-713. https://doi.org/10.1038/oby.2007.95
Strandberg L, Mellström D, Ljunggren Ö, Grundberg E, Karlsson MK, Holmberg AH et al. IL6 and IL1B polymorphisms are associated with fat mass in older men: The MrOS study Sweden. Obesity. 2008 Mar;16(3):710-713. https://doi.org/10.1038/oby.2007.95
Strandberg, Louise ; Mellström, Dan ; Ljunggren, Östen ; Grundberg, Elin ; Karlsson, Magnus K. ; Holmberg, Anna H. ; Orwoll, Eric ; Eriksson, Anna L. ; Svedberg, Johan ; Bengtsson, Magnus ; Ohlsson, Claes ; Jansson, John Olov. / IL6 and IL1B polymorphisms are associated with fat mass in older men : The MrOS study Sweden. In: Obesity. 2008 ; Vol. 16, No. 3. pp. 710-713.
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