IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R α and γ chains

Yuan K. Chou, Dennis Bourdette, David Barnes, Thomas P. Finn, Susan Murray, Laura Unsicker, Ian Robey, Ruth Whitham, Abigail C. Buenafe, Mark Allegretta, Halina Offner, Arthur Vandenbark

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Interleukin-7 has demonstrated potent enhancing effects on the growth and differentiation of several immature celt types, including thymocytes, and on survival of resting and antigen activated T cells. In this study, we evaluated the effects of IL-7 on post-thymic antigen-specific T cells from human blood. IL-7 was found to enhance proliferation responses and IFN-γ secretion of myelin or recall Ag-specific Th1 cells through the selective up- regulation of the IL-2Rα and γ but not β chains in both an Ag-dependent and Ag-independent manner, but did not affect monocytes, B cells, or NK cells. These functions of IL-7 enhanced the detection of Th1 but not Th2 cell frequency by > 2.5 fold, and promoted selection of Ag-specific Th1 cells by the limiting dilution method. Moreover, IL-7 pretreatment conferred increased resistance of CD4 + T cells to CD8 + cell lysis. These studies demonstrate that IL-7 promotes the growth and survival of circulating Ag-specific human Th1 cells through a mechanism that probably involves the γc common receptor for IL-2 family members that includes IL-7.

Original languageEnglish (US)
Pages (from-to)101-111
Number of pages11
JournalJournal of Neuroimmunology
Volume96
Issue number1
DOIs
Publication statusPublished - Apr 1 1999

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Keywords

  • Human T cells
  • IL-2R
  • IL-7
  • Survival factor

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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