Abstract
Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and in its progression to acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates immune responses and plays a pathogenic role in HIV-1 infection by enhancing viral replication. Single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter region may lead to altered transcriptional activity and IL-18 production, and may account for variation in the risk of HIV-1 infection. We have investigated the association between IL-18 promoter polymorphism -607C>A and HIV-1 infection through a case-control study of 500 patients with HIV-1/AIDS and an equal number of age and sex matched controls in a north Indian population. Genotyping using sequence specific primer-polymerase chain reaction (SSP-PCR) showed a statistically significant reduced risk of HIV-1 infection for the A>A genotype [odds ratio (OR) = 0.57, 95% confidence interval (95% CI) = 0.33-0.98, p = 0.040], but not for the C>A genotype (OR = 0.87, 95% CI = 0.66-1.14, p = 0.321). We concluded that the -607A allele of the IL-18 gene promoter polymorphism may play a protective role against the progression of HIV-1 infection in this population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-48 |
| Number of pages | 8 |
| Journal | Balkan Journal of Medical Genetics |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2011 |
| Externally published | Yes |
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Keywords
- Acquired immune deficiency syndrome (AIDS)
- Human immnunodeficiency virus type 1 (HIV-1)
- IL-18 gene
- Sequence specific primer-polymerase chain reaction (SSP-PCR)
- Single nucleotide polymorphisms (SNPs)
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population. / Sobti, R. C.; Sharma, V. L.; Abitew, A. M.; Berhane, N.; Mahdi, S. A.; Askari, M.; Kuttiat, V. S.; Wanchu, Ajay.
In: Balkan Journal of Medical Genetics, Vol. 14, No. 2, 01.01.2011, p. 41-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population
AU - Sobti, R. C.
AU - Sharma, V. L.
AU - Abitew, A. M.
AU - Berhane, N.
AU - Mahdi, S. A.
AU - Askari, M.
AU - Kuttiat, V. S.
AU - Wanchu, Ajay
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and in its progression to acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates immune responses and plays a pathogenic role in HIV-1 infection by enhancing viral replication. Single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter region may lead to altered transcriptional activity and IL-18 production, and may account for variation in the risk of HIV-1 infection. We have investigated the association between IL-18 promoter polymorphism -607C>A and HIV-1 infection through a case-control study of 500 patients with HIV-1/AIDS and an equal number of age and sex matched controls in a north Indian population. Genotyping using sequence specific primer-polymerase chain reaction (SSP-PCR) showed a statistically significant reduced risk of HIV-1 infection for the A>A genotype [odds ratio (OR) = 0.57, 95% confidence interval (95% CI) = 0.33-0.98, p = 0.040], but not for the C>A genotype (OR = 0.87, 95% CI = 0.66-1.14, p = 0.321). We concluded that the -607A allele of the IL-18 gene promoter polymorphism may play a protective role against the progression of HIV-1 infection in this population.
AB - Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and in its progression to acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates immune responses and plays a pathogenic role in HIV-1 infection by enhancing viral replication. Single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter region may lead to altered transcriptional activity and IL-18 production, and may account for variation in the risk of HIV-1 infection. We have investigated the association between IL-18 promoter polymorphism -607C>A and HIV-1 infection through a case-control study of 500 patients with HIV-1/AIDS and an equal number of age and sex matched controls in a north Indian population. Genotyping using sequence specific primer-polymerase chain reaction (SSP-PCR) showed a statistically significant reduced risk of HIV-1 infection for the A>A genotype [odds ratio (OR) = 0.57, 95% confidence interval (95% CI) = 0.33-0.98, p = 0.040], but not for the C>A genotype (OR = 0.87, 95% CI = 0.66-1.14, p = 0.321). We concluded that the -607A allele of the IL-18 gene promoter polymorphism may play a protective role against the progression of HIV-1 infection in this population.
KW - Acquired immune deficiency syndrome (AIDS)
KW - Human immnunodeficiency virus type 1 (HIV-1)
KW - IL-18 gene
KW - Sequence specific primer-polymerase chain reaction (SSP-PCR)
KW - Single nucleotide polymorphisms (SNPs)
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UR - http://www.scopus.com/inward/citedby.url?scp=83655172755&partnerID=8YFLogxK
U2 - 10.2478/v10034-011-0046-8
DO - 10.2478/v10034-011-0046-8
M3 - Article
VL - 14
SP - 41
EP - 48
JO - Balkan Journal of Medical Genetics
JF - Balkan Journal of Medical Genetics
SN - 1311-0160
IS - 2
ER -