IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population

R. C. Sobti, V. L. Sharma, A. M. Abitew, N. Berhane, S. A. Mahdi, M. Askari, V. S. Kuttiat, Ajay Wanchu

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Abstract

Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and in its progression to acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates immune responses and plays a pathogenic role in HIV-1 infection by enhancing viral replication. Single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter region may lead to altered transcriptional activity and IL-18 production, and may account for variation in the risk of HIV-1 infection. We have investigated the association between IL-18 promoter polymorphism -607C>A and HIV-1 infection through a case-control study of 500 patients with HIV-1/AIDS and an equal number of age and sex matched controls in a north Indian population. Genotyping using sequence specific primer-polymerase chain reaction (SSP-PCR) showed a statistically significant reduced risk of HIV-1 infection for the A>A genotype [odds ratio (OR) = 0.57, 95% confidence interval (95% CI) = 0.33-0.98, p = 0.040], but not for the C>A genotype (OR = 0.87, 95% CI = 0.66-1.14, p = 0.321). We concluded that the -607A allele of the IL-18 gene promoter polymorphism may play a protective role against the progression of HIV-1 infection in this population.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalBalkan Journal of Medical Genetics
Volume14
Issue number2
DOIs
Publication statusPublished - Jan 1 2011
Externally publishedYes

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Sobti, R. C., Sharma, V. L., Abitew, A. M., Berhane, N., Mahdi, S. A., Askari, M., ... Wanchu, A. (2011). IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population. Balkan Journal of Medical Genetics, 14(2), 41-48. https://doi.org/10.2478/v10034-011-0046-8