IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population

R. C. Sobti, V. L. Sharma, A. M. Abitew, N. Berhane, S. A. Mahdi, M. Askari, V. S. Kuttiat, Ajay Wanchu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several host genetic factors play an important role in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and in its progression to acquired immune deficiency syndrome (AIDS). The interleukin-18 (IL-18) is a multifunctional proinflammatory cytokine that regulates immune responses and plays a pathogenic role in HIV-1 infection by enhancing viral replication. Single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter region may lead to altered transcriptional activity and IL-18 production, and may account for variation in the risk of HIV-1 infection. We have investigated the association between IL-18 promoter polymorphism -607C>A and HIV-1 infection through a case-control study of 500 patients with HIV-1/AIDS and an equal number of age and sex matched controls in a north Indian population. Genotyping using sequence specific primer-polymerase chain reaction (SSP-PCR) showed a statistically significant reduced risk of HIV-1 infection for the A>A genotype [odds ratio (OR) = 0.57, 95% confidence interval (95% CI) = 0.33-0.98, p = 0.040], but not for the C>A genotype (OR = 0.87, 95% CI = 0.66-1.14, p = 0.321). We concluded that the -607A allele of the IL-18 gene promoter polymorphism may play a protective role against the progression of HIV-1 infection in this population.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalBalkan Journal of Medical Genetics
Volume14
Issue number2
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Interleukin-18
Genetic Promoter Regions
Virus Diseases
HIV-1
Population
Genes
Acquired Immunodeficiency Syndrome
Odds Ratio
Genotype
Confidence Intervals
Single Nucleotide Polymorphism
Case-Control Studies
Alleles
Cytokines
Polymerase Chain Reaction

Keywords

  • Acquired immune deficiency syndrome (AIDS)
  • Human immnunodeficiency virus type 1 (HIV-1)
  • IL-18 gene
  • Sequence specific primer-polymerase chain reaction (SSP-PCR)
  • Single nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Sobti, R. C., Sharma, V. L., Abitew, A. M., Berhane, N., Mahdi, S. A., Askari, M., ... Wanchu, A. (2011). IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population. Balkan Journal of Medical Genetics, 14(2), 41-48. https://doi.org/10.2478/v10034-011-0046-8

IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population. / Sobti, R. C.; Sharma, V. L.; Abitew, A. M.; Berhane, N.; Mahdi, S. A.; Askari, M.; Kuttiat, V. S.; Wanchu, Ajay.

In: Balkan Journal of Medical Genetics, Vol. 14, No. 2, 01.01.2011, p. 41-48.

Research output: Contribution to journalArticle

Sobti, RC, Sharma, VL, Abitew, AM, Berhane, N, Mahdi, SA, Askari, M, Kuttiat, VS & Wanchu, A 2011, 'IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population', Balkan Journal of Medical Genetics, vol. 14, no. 2, pp. 41-48. https://doi.org/10.2478/v10034-011-0046-8
Sobti, R. C. ; Sharma, V. L. ; Abitew, A. M. ; Berhane, N. ; Mahdi, S. A. ; Askari, M. ; Kuttiat, V. S. ; Wanchu, Ajay. / IL-18 gene promoter region 607C/A polymorphism in HIV-1 infected north Indian population. In: Balkan Journal of Medical Genetics. 2011 ; Vol. 14, No. 2. pp. 41-48.
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