IGFs and IGF binding proteins in human breast cancer cell lines

D. M. Wilson, D. D. Deleon, B. Bakker, G. Lamson, R. G. Rosenfeld

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrated that these hBCCL have both Type 1 and 2 IGF receptors and, in data not shown, can respond to small amounts of exogenous IGFs. These cells also secrete a variety of different IGF-BPs into CM. While many of these secreted IGF-BPs appear related to the three recently characterized human IGF-BPs, the identity of the prominent 24 kD band remains unknown. It is clear that these high affinity IGF-BPs can confound attempts to detect either IGF-I or -II by radioligand assay and must be carefully removed before such assays. While it is tempting to hypothesize that these IGF-BPs act in a paracrine or autocrine manner to modulate the effects of IGF-I and -II, the physiological role of these IGF-BPs remains unclear.

Original languageEnglish (US)
Title of host publicationInsuline-like Growth Factor binding proteins
Subtitle of host publicationproceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881
EditorsS.L.S. Drop, R.L. Hintz, S.L.S. Drop, R.L. Hintz
PublisherElsevier Science Publishers B.V.
Pages241-247
Number of pages7
ISBN (Print)0444811834
StatePublished - Dec 1 1989
EventA workshop on Insuline-like Growth Factor binding proteins -
Duration: Jun 17 1989Jun 19 1989

Publication series

NameInsuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881

Other

OtherA workshop on Insuline-like Growth Factor binding proteins
Period6/17/896/19/89

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wilson, D. M., Deleon, D. D., Bakker, B., Lamson, G., & Rosenfeld, R. G. (1989). IGFs and IGF binding proteins in human breast cancer cell lines. In S. L. S. Drop, R. L. Hintz, S. L. S. Drop, & R. L. Hintz (Eds.), Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881 (pp. 241-247). (Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881). Elsevier Science Publishers B.V..