IGFs and IGF binding proteins in human breast cancer cell lines

D. M. Wilson, D. D. Deleon, B. Bakker, G. Lamson, Ronald (Ron) Rosenfeld

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrated that these hBCCL have both Type 1 and 2 IGF receptors and, in data not shown, can respond to small amounts of exogenous IGFs. These cells also secrete a variety of different IGF-BPs into CM. While many of these secreted IGF-BPs appear related to the three recently characterized human IGF-BPs, the identity of the prominent 24 kD band remains unknown. It is clear that these high affinity IGF-BPs can confound attempts to detect either IGF-I or -II by radioligand assay and must be carefully removed before such assays. While it is tempting to hypothesize that these IGF-BPs act in a paracrine or autocrine manner to modulate the effects of IGF-I and -II, the physiological role of these IGF-BPs remains unclear.

Original languageEnglish (US)
Title of host publicationInsuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881
EditorsS.L.S. Drop, R.L. Hintz, S.L.S. Drop, R.L. Hintz
PublisherElsevier Science Publishers B.V.
Pages241-247
Number of pages7
ISBN (Print)0444811834
StatePublished - 1989
Externally publishedYes
EventA workshop on Insuline-like Growth Factor binding proteins -
Duration: Jun 17 1989Jun 19 1989

Other

OtherA workshop on Insuline-like Growth Factor binding proteins
Period6/17/896/19/89

Fingerprint

Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Breast Neoplasms
IGF Type 2 Receptor
Cell Line
Radioligand Assay
IGF Type 1 Receptor
Insulin-Like Growth Factor II

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wilson, D. M., Deleon, D. D., Bakker, B., Lamson, G., & Rosenfeld, R. R. (1989). IGFs and IGF binding proteins in human breast cancer cell lines. In S. L. S. Drop, R. L. Hintz, S. L. S. Drop, & R. L. Hintz (Eds.), Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881 (pp. 241-247). Elsevier Science Publishers B.V..

IGFs and IGF binding proteins in human breast cancer cell lines. / Wilson, D. M.; Deleon, D. D.; Bakker, B.; Lamson, G.; Rosenfeld, Ronald (Ron).

Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881. ed. / S.L.S. Drop; R.L. Hintz; S.L.S. Drop; R.L. Hintz. Elsevier Science Publishers B.V., 1989. p. 241-247.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wilson, DM, Deleon, DD, Bakker, B, Lamson, G & Rosenfeld, RR 1989, IGFs and IGF binding proteins in human breast cancer cell lines. in SLS Drop, RL Hintz, SLS Drop & RL Hintz (eds), Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881. Elsevier Science Publishers B.V., pp. 241-247, A workshop on Insuline-like Growth Factor binding proteins, 6/17/89.
Wilson DM, Deleon DD, Bakker B, Lamson G, Rosenfeld RR. IGFs and IGF binding proteins in human breast cancer cell lines. In Drop SLS, Hintz RL, Drop SLS, Hintz RL, editors, Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881. Elsevier Science Publishers B.V. 1989. p. 241-247
Wilson, D. M. ; Deleon, D. D. ; Bakker, B. ; Lamson, G. ; Rosenfeld, Ronald (Ron). / IGFs and IGF binding proteins in human breast cancer cell lines. Insuline-like Growth Factor binding proteins: proceedings of a workshop on Insuline-like Growth Factor binding proteins. ICS881. editor / S.L.S. Drop ; R.L. Hintz ; S.L.S. Drop ; R.L. Hintz. Elsevier Science Publishers B.V., 1989. pp. 241-247
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