Abstract
The proposed insulin-like growth factor binding protein (IGFBP) superfamily are a group of secreted proteins that are structurally, functionally and evolutionarily related, and include six IGFBPs and over 10 IGFBP-related proteins. The IGFBPs have high affinities for insulin-like growth factors (IGFs), thereby modulating the mitogenic, anti-apoptotic and metabolic actions of IGFs. In addition, IGFBPs, particularly IGFBP-3, also have IGF-independent, anti-proliferative and pro-apoptotic functions. The IGFBPs are, in turn, modulated by proteolysis. Epidemiological data correlating serum IGF/ IGFBP levels with the risk of several human cancers suggest a possible protective role for IGFBP-3. In vitro studies suggest that the potential protective effects of IGFBP-3 involve both IGF-dependent and IGF-independent mechanisms. Further studies are necessary to demonstrate whether the ability of IGFBPs to inhibit the proliferation of cancer cells under in vitro conditions has significant clinical implications.
| Original language | English (US) |
|---|---|
| Title of host publication | Biology of IGF-1 |
| Subtitle of host publication | Its Interaction with Insulin in Health and Malignant States |
| Publisher | wiley |
| Pages | 215-230 |
| Number of pages | 16 |
| Volume | 262 |
| ISBN (Electronic) | 9780470869970 |
| ISBN (Print) | 9780470869987 |
| DOIs | |
| State | Published - Oct 7 2008 |
| Externally published | Yes |
Keywords
- Altered serum IGFs and IGFBP-3 concentrations
- Conserved N-terminal domain
- IGF-binding affinity of IGFBPs
- IGF-dependent and IGF-independent mechanisms
- IGFBP inhibitory effects regulation
- IGFBP superfamily
- IGFBP-3 and antitumorigenesis
- IGFBPs and human cancer
- Insulin-like growth factor binding protein (IGFBP)
- Matrix metalloproteinases (MMPs)
ASJC Scopus subject areas
- General Medicine