IGF-1 and prostate cancer

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    By virtue of their potent proliferative and anti-apoptotic effects, the insulin-like growth factors (IGFs) have been the subject of long-term scrutiny for their role in tumorigenesis. With regard to prostate cancer in particular, IGF-1 has been shown to stimulate the proliferation of human prostate epithelial cells in culture and to be necessary for normal growth and development of the rat and mouse prostate. Epidemiological studies have established a link between high circulating serum IGF-1 levels and the risk of later developing advanced prostate cancer, and overexpression of IGF-1 in the prostate basal epithelial layer of transgenic mice results in prostate adenocarcinoma that is similar to human disease. Thus, IGF-1 action appears to be important for prostate cancer initiation. On the other hand, decreased IGF action, subsequent to the down-regulation of IGF-1 receptor expression, is associated with advanced, metastatic disease. This decrease in IGF-1 receptor may confer a survival advantage to prostate cancer cells that have entered the circulation by making them resistant to the differentiative effects of IGF-1 at metastatic sites such as bone. The molecular mechanisms that effect IGF-1 receptor down-regulation appear to involve novel oncogenic functions of the Wilms' tumour suppressor, as well as novel actions of the androgen receptor.

    Original languageEnglish (US)
    Title of host publicationBiology of IGF-1
    Subtitle of host publicationIts Interaction with Insulin in Health and Malignant States
    Publisherwiley
    Pages193-199
    Number of pages7
    Volume262
    ISBN (Electronic)9780470869970
    ISBN (Print)9780470869987
    DOIs
    Publication statusPublished - Oct 7 2008

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    Keywords

    • Circulating IGF-1 levels
    • IGF binding proteins (IGFBPs)
    • IGF-1 action in prostate cancer
    • IGF-1 and IGF-1 signalling therapy
    • Insulin-like growth factors (IGFs) and tumorigenesis
    • Overexpression of the IGF-1R
    • Prostate cancer initiation
    • WT1 Wilms' tumour suppressor gene product

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Roberts, C. (2008). IGF-1 and prostate cancer. In Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States (Vol. 262, pp. 193-199). wiley. https://doi.org/10.1002/0470869976.ch12