Abstract
OBJECTIVE: To investigate the expression of IGF-1 receptors and insulin receptors on the minor salivary gland (MSG) tissues of patients diagnosed with Sjögren's syndrome (SS) and normal salivary gland tissue surrounding mucoceles. SUBJECTS AND METHODS: Five MSG tissue sections from SS and seven from mucocele patients were stained immunohistochemically using antibody to IGF-1 receptor and insulin receptor in a horse radish peroxidase and DAB system. RESULTS: The expression of the insulin receptor was increased in the SS sections compared with controls, while the insulin-like growth factor-1 receptor was more intensely expressed in the controls. CONCLUSION: The presence of differential expression of receptors for IGF and insulin might suggest a possible role of these growth factors in the pathogenesis of SS.
Original language | English (US) |
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Pages (from-to) | 7-13 |
Number of pages | 7 |
Journal | Oral Diseases |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2003 |
Externally published | Yes |
Keywords
- Insulin receptor
- Insulin-like growth factor-1 receptor
- Sjögren's syndrome
ASJC Scopus subject areas
- Otorhinolaryngology
- General Dentistry