IGF-1 and insulin receptor expression in the minor salivary gland tissues of Sjögren's syndrome and mucoceles - Immunohistochemical study

J. Katz, Mary Stavropoulos, D. Cohen, J. Robledo, C. Stewart, M. Heft

Research output: Contribution to journalArticle

12 Scopus citations


OBJECTIVE: To investigate the expression of IGF-1 receptors and insulin receptors on the minor salivary gland (MSG) tissues of patients diagnosed with Sjögren's syndrome (SS) and normal salivary gland tissue surrounding mucoceles. SUBJECTS AND METHODS: Five MSG tissue sections from SS and seven from mucocele patients were stained immunohistochemically using antibody to IGF-1 receptor and insulin receptor in a horse radish peroxidase and DAB system. RESULTS: The expression of the insulin receptor was increased in the SS sections compared with controls, while the insulin-like growth factor-1 receptor was more intensely expressed in the controls. CONCLUSION: The presence of differential expression of receptors for IGF and insulin might suggest a possible role of these growth factors in the pathogenesis of SS.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalOral Diseases
Issue number1
Publication statusPublished - Jan 1 2003
Externally publishedYes



  • Insulin receptor
  • Insulin-like growth factor-1 receptor
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

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