IgA and IgA-specific receptors in human disease: Structural and functional insights into pathogenesis and therapeutic potential

Michelle M. Gomes, Andrew B. Herr

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

IgA antibodies play an important role in humoral immunity. IgA is the predominant antibody in mucosal secretions and the second most prevalent in the serum. It occupies a unique position among human antibodies in that it can both trigger and suppress inflammatory responses, depending on the situation. Recent structural and functional studies have revealed details of the structure of IgA and its interaction with key cell-surface receptors. We look at the role IgA and IgA receptors (particularly FcαRI) play in the pathogenesis of diseases such as IgA nephropathy and other autoimmune conditions. Finally, we address the potential of IgA as a therapeutic tool to either trigger specific inflammatory responses to destroy target cells or suppress inflammatory responses in the case of autoimmune diseases, and the promise of mucosal vaccines for eliciting specific IgA responses to pathogens in mucosal environments.

Original languageEnglish (US)
Pages (from-to)383-395
Number of pages13
JournalSpringer Seminars in Immunopathology
Volume28
Issue number4
DOIs
StatePublished - Dec 2006
Externally publishedYes

Keywords

  • FcαRI
  • IgA nephropathy
  • TfR
  • X-ray crystallography
  • pIgR

ASJC Scopus subject areas

  • Immunology

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