Idiotypic mimicry of a cell surface DNA receptor: Evidence for anti-DNA antibodies being a subset of anti-anti-DNA receptor antibodies

R. M. Bennett, K. A. Cornell, M. J. Merritt, A. C. Bakke, D. Mourich, S. H. Hefeneider

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Anti-idiotypic anti-DNA antibodies (anti-anti-DNA) have previously been described in both patients with systemic lupus erythematosus and healthy individuals. Jerne's hypothesis predicts that such antibodies would bear a paratope reactive with non-sequence specific DNA binding proteins. Here we have explored the notion of a molecular mimicry between anti-anti-DNA antibodies and antibodies to a previously described 28-29 kD cell surface DNA binding molecule. It was shown that affinity purified anti-anti-DNA antibodies inhibit the binding of DNA to cells and that MoAb to the 28-29 kD receptor react with anti-DNA antibodies. These findings indicate that a subset of anti-anti-DNA antibodies are idiotypically related to antibodies reactive with a cell surface DNA binding molecule. It is hypothesized that anti-DNA antibodies may arise when a convergence of genetic and environmental influences favours an unrestrained anti-idiotypic response to cell surface DNA binding molecule(s).

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalClinical and Experimental Immunology
Volume90
Issue number3
DOIs
StatePublished - 1992

Keywords

  • DNA receptor
  • anti-DNA antibodies
  • anti-idiotypic anti-DNA antibodies
  • anti-receptor antibodies
  • idiotypic mimicry

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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