11 patients with kidney stone disease and idiopathic hypercalciuria (urinary calcium above 4 mg/kg/j), without phosphorus renal leak and 6 control subjects were put for 3 days on a diet containing 1 g calcium and 1 phosphorus daily (period A), and then for 4 days on a diet containing 1 g calcium, 450 mg phosphorus and 3 g aluminium hydroxide daily (period B). During period A, no significant difference in blood calcium, phosphorus and magnesium, phosphaturia, rate of phosphorus reabsorption (RPR) and ratio maximum RPR/creatinine clearance was found between the two groups. After 2 days on a low phosphate diet (period B) the blood phosphorus decreased significantly in the hypercalciuric patients thus revealing a latent abnormality in the retention of phosphates in them. This abnormality could play an important role in the pathogenesis of hypercalciuria.
|Translated title of the contribution||Idiopathic hypercalciuria: Effects of acute phosphorus deficiency|
|Number of pages||4|
|Journal||Nouvelle Presse Medicale|
|State||Published - Dec 1 1979|
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