Idiopathic bilateral lipid keratopathy

E. Alfonso, L. Arrellanes, S. A. Boruchoff, L. D. Ormerod, Daniel Albert

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17 Scopus citations


A 52-year-old Mexican man presented with asymptomatic, bilaterally symmetrical lipid infiltrates of the cornea and adjacent limbus. No evidence of previous ocular disease or systemic disorder of lipid metabolism could be detected. Penetrating keratoplasty of the right eye was required. The cornea was rigid and thick, with posterior bulging into the anterior chamber. Light microscopy revealed deep corneal lipid granules, foamy histiocytes, vascularisation, and chronic non-granulomatous inflammation. Transmission electron microscopy showed extracellular lipid spaces and numerous intracytoplasmic lipid vascuoles in histiocytes, keratocytes, conjunctival epithelium, and the endothelium of blood vessels in the corneal stroma and adjacent limbal conjunctiva. Histochemical analysis revealed the presence of neutral fats, free fatty acids, cholesterol, and phospholipids.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalBritish Journal of Ophthalmology
Issue number5
Publication statusPublished - Jan 1 1988
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Alfonso, E., Arrellanes, L., Boruchoff, S. A., Ormerod, L. D., & Albert, D. (1988). Idiopathic bilateral lipid keratopathy. British Journal of Ophthalmology, 72(5), 338-343.