Idiopathic bilateral lipid keratopathy

E. Alfonso, L. Arrellanes, S. A. Boruchoff, L. D. Ormerod, Daniel Albert

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A 52-year-old Mexican man presented with asymptomatic, bilaterally symmetrical lipid infiltrates of the cornea and adjacent limbus. No evidence of previous ocular disease or systemic disorder of lipid metabolism could be detected. Penetrating keratoplasty of the right eye was required. The cornea was rigid and thick, with posterior bulging into the anterior chamber. Light microscopy revealed deep corneal lipid granules, foamy histiocytes, vascularisation, and chronic non-granulomatous inflammation. Transmission electron microscopy showed extracellular lipid spaces and numerous intracytoplasmic lipid vascuoles in histiocytes, keratocytes, conjunctival epithelium, and the endothelium of blood vessels in the corneal stroma and adjacent limbal conjunctiva. Histochemical analysis revealed the presence of neutral fats, free fatty acids, cholesterol, and phospholipids.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalBritish Journal of Ophthalmology
Volume72
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Lipids
Histiocytes
Limbus Corneae
Lipid Metabolism Disorders
Corneal Stroma
Penetrating Keratoplasty
Eye Diseases
Conjunctiva
Extracellular Space
Anterior Chamber
Transmission Electron Microscopy
Nonesterified Fatty Acids
Cornea
Endothelium
Blood Vessels
Microscopy
Phospholipids
Epithelium
Fats
Cholesterol

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Alfonso, E., Arrellanes, L., Boruchoff, S. A., Ormerod, L. D., & Albert, D. (1988). Idiopathic bilateral lipid keratopathy. British Journal of Ophthalmology, 72(5), 338-343. https://doi.org/10.1136/bjo.72.5.338

Idiopathic bilateral lipid keratopathy. / Alfonso, E.; Arrellanes, L.; Boruchoff, S. A.; Ormerod, L. D.; Albert, Daniel.

In: British Journal of Ophthalmology, Vol. 72, No. 5, 01.01.1988, p. 338-343.

Research output: Contribution to journalArticle

Alfonso, E, Arrellanes, L, Boruchoff, SA, Ormerod, LD & Albert, D 1988, 'Idiopathic bilateral lipid keratopathy', British Journal of Ophthalmology, vol. 72, no. 5, pp. 338-343. https://doi.org/10.1136/bjo.72.5.338
Alfonso E, Arrellanes L, Boruchoff SA, Ormerod LD, Albert D. Idiopathic bilateral lipid keratopathy. British Journal of Ophthalmology. 1988 Jan 1;72(5):338-343. https://doi.org/10.1136/bjo.72.5.338
Alfonso, E. ; Arrellanes, L. ; Boruchoff, S. A. ; Ormerod, L. D. ; Albert, Daniel. / Idiopathic bilateral lipid keratopathy. In: British Journal of Ophthalmology. 1988 ; Vol. 72, No. 5. pp. 338-343.
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