Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice

Lauren C. Milner, Kari J. Buck

Research output: Chapter in Book/Report/Conference proceedingChapter

21 Scopus citations

Abstract

Alcoholism is a complex clinical disorder with genetic and environmental contributions. Although no animal model duplicates alcoholism, models for specific factors, such as the withdrawal syndrome, are useful to identify potential genetic determinants of liability in humans. Murine models have been invaluable to identify quantitative trait loci (QTLs) that influence a variety of alcohol responses. However, the QTL regions are typically large, at least initially, and contain numerous genes, making identification of the causal quantitative trait gene(s) (QTGs) challenging. Here, we present QTG identification strategies currently used in the field of alcohol genetics and discuss relevance to alcoholic human populations.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Pages173-204
Number of pages32
EditionC
DOIs
StatePublished - Jan 1 2010

Publication series

NameInternational Review of Neurobiology
NumberC
Volume91
ISSN (Print)0074-7742

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Keywords

  • Alcohol dependence
  • Alcohol withdrawal
  • Candidate gene
  • Mouse model
  • QTG
  • QTL mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Milner, L. C., & Buck, K. J. (2010). Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice. In International Review of Neurobiology (C ed., pp. 173-204). (International Review of Neurobiology; Vol. 91, No. C). Academic Press Inc.. https://doi.org/10.1016/S0074-7742(10)91006-4