Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice

Lauren C. Milner, Kari Buck

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Alcoholism is a complex clinical disorder with genetic and environmental contributions. Although no animal model duplicates alcoholism, models for specific factors, such as the withdrawal syndrome, are useful to identify potential genetic determinants of liability in humans. Murine models have been invaluable to identify quantitative trait loci (QTLs) that influence a variety of alcohol responses. However, the QTL regions are typically large, at least initially, and contain numerous genes, making identification of the causal quantitative trait gene(s) (QTGs) challenging. Here, we present QTG identification strategies currently used in the field of alcohol genetics and discuss relevance to alcoholic human populations.

Original languageEnglish (US)
Pages (from-to)173-204
Number of pages32
JournalInternational Review of Neurobiology
Volume91
Issue numberC
DOIs
StatePublished - 2010

Fingerprint

Quantitative Trait Loci
Alcohols
Phenotype
Alcoholism
Genes
Inborn Genetic Diseases
Alcoholics
Animal Models
Population

Keywords

  • Alcohol dependence
  • Alcohol withdrawal
  • Candidate gene
  • Mouse model
  • QTG
  • QTL mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice. / Milner, Lauren C.; Buck, Kari.

In: International Review of Neurobiology, Vol. 91, No. C, 2010, p. 173-204.

Research output: Contribution to journalArticle

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