Identifying Quantitative Trait Loci (QTLs) and Genes (QTGs) for Alcohol-Related Phenotypes in Mice

Lauren C. Milner, Kari J. Buck

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations


Alcoholism is a complex clinical disorder with genetic and environmental contributions. Although no animal model duplicates alcoholism, models for specific factors, such as the withdrawal syndrome, are useful to identify potential genetic determinants of liability in humans. Murine models have been invaluable to identify quantitative trait loci (QTLs) that influence a variety of alcohol responses. However, the QTL regions are typically large, at least initially, and contain numerous genes, making identification of the causal quantitative trait gene(s) (QTGs) challenging. Here, we present QTG identification strategies currently used in the field of alcohol genetics and discuss relevance to alcoholic human populations.

Original languageEnglish (US)
Title of host publicationInternational Review of Neurobiology
PublisherAcademic Press Inc.
Number of pages32
StatePublished - 2010

Publication series

NameInternational Review of Neurobiology
ISSN (Print)0074-7742


  • Alcohol dependence
  • Alcohol withdrawal
  • Candidate gene
  • Mouse model
  • QTG
  • QTL mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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