Identifying predictors of central nervous system disease in solid organ transplant recipientswith cryptococcosis

Ryosuke Osawa, Barbara D. Alexander, Olivier Lortholary, Françoise Dromer, Graeme N. Forrest, G. Marshall Lyon, Jyoti Somani, Krishan L. Gupta, Ramon Del Busto, Timothy L. Pruett, Costi D. Sifri, Ajit P. Limaye, George T. John, Goran B. Klintmalm, Kenneth Pursell, Valentina Stosor, Michele I. Morris, Lorraine A. Dowdy, Patricia Muñoz, Andre C. KalilJulia Garcia-Diaz, Susan Orloff, Andrew A. House, Sally Houston, Dannah Wray, Shirish Huprikar, Leonard B. Johnson, Atul Humar, Raymund R. Razonable, Robert A. Fisher, Shahid Husain, Marilyn M. Wagener, Nina Singh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

BACKGROUND: Cerebrospinal fluid (CSF) analysis is often deferred in patients with cryptococcal disease, particularly in the absence of neurologic manifestations. We sought to determine whether a subset of solid organ transplant (SOT) recipients with high likelihood of central nervous system (CNS) disease could be identified in whom CSF analysis must be performed. METHODS: Patients comprised a multicenter cohort of SOT recipients with cryptococcosis. RESULTS: Of 129 (88%) of 146 SOT recipients with cryptococcosis who underwent CSF analysis, 80 (62%) had CNS disease. In the overall study population, abnormal mental status, time to onset of cryptococcosis more than 24 months posttransplantation (late-onset disease), serum cryptococcal antigen titer more than 1:64, and fungemia were independently associated with an increased risk of CNS disease. Of patients with abnormal mental status, 95% had CNS cryptococcosis. When only patients with normal mental status were considered, three predictors (serum antigen titer >1:64, fungemia, and late-onset disease) independently identified patients with CNS cryptococcosis; the risk of CNS disease was 14% if none, 39% if one, and 94% if two of the aforementioned predictors existed (χ for trend P

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalTransplantation
Volume89
Issue number1
DOIs
StatePublished - Jan 2010
Externally publishedYes

Fingerprint

Cryptococcosis
Central Nervous System Diseases
Transplants
Fungemia
Cerebrospinal Fluid
Central Nervous System
Antigens
Neurologic Manifestations
Serum
Population
Transplant Recipients

Keywords

  • Central nervous system disease.
  • Cryptococcosis
  • Solid organ transplant

ASJC Scopus subject areas

  • Transplantation

Cite this

Osawa, R., Alexander, B. D., Lortholary, O., Dromer, F., Forrest, G. N., Lyon, G. M., ... Singh, N. (2010). Identifying predictors of central nervous system disease in solid organ transplant recipientswith cryptococcosis. Transplantation, 89(1), 69-74. https://doi.org/10.1097/TP.0b013e3181bcda41

Identifying predictors of central nervous system disease in solid organ transplant recipientswith cryptococcosis. / Osawa, Ryosuke; Alexander, Barbara D.; Lortholary, Olivier; Dromer, Françoise; Forrest, Graeme N.; Lyon, G. Marshall; Somani, Jyoti; Gupta, Krishan L.; Del Busto, Ramon; Pruett, Timothy L.; Sifri, Costi D.; Limaye, Ajit P.; John, George T.; Klintmalm, Goran B.; Pursell, Kenneth; Stosor, Valentina; Morris, Michele I.; Dowdy, Lorraine A.; Muñoz, Patricia; Kalil, Andre C.; Garcia-Diaz, Julia; Orloff, Susan; House, Andrew A.; Houston, Sally; Wray, Dannah; Huprikar, Shirish; Johnson, Leonard B.; Humar, Atul; Razonable, Raymund R.; Fisher, Robert A.; Husain, Shahid; Wagener, Marilyn M.; Singh, Nina.

In: Transplantation, Vol. 89, No. 1, 01.2010, p. 69-74.

Research output: Contribution to journalArticle

Osawa, R, Alexander, BD, Lortholary, O, Dromer, F, Forrest, GN, Lyon, GM, Somani, J, Gupta, KL, Del Busto, R, Pruett, TL, Sifri, CD, Limaye, AP, John, GT, Klintmalm, GB, Pursell, K, Stosor, V, Morris, MI, Dowdy, LA, Muñoz, P, Kalil, AC, Garcia-Diaz, J, Orloff, S, House, AA, Houston, S, Wray, D, Huprikar, S, Johnson, LB, Humar, A, Razonable, RR, Fisher, RA, Husain, S, Wagener, MM & Singh, N 2010, 'Identifying predictors of central nervous system disease in solid organ transplant recipientswith cryptococcosis', Transplantation, vol. 89, no. 1, pp. 69-74. https://doi.org/10.1097/TP.0b013e3181bcda41
Osawa, Ryosuke ; Alexander, Barbara D. ; Lortholary, Olivier ; Dromer, Françoise ; Forrest, Graeme N. ; Lyon, G. Marshall ; Somani, Jyoti ; Gupta, Krishan L. ; Del Busto, Ramon ; Pruett, Timothy L. ; Sifri, Costi D. ; Limaye, Ajit P. ; John, George T. ; Klintmalm, Goran B. ; Pursell, Kenneth ; Stosor, Valentina ; Morris, Michele I. ; Dowdy, Lorraine A. ; Muñoz, Patricia ; Kalil, Andre C. ; Garcia-Diaz, Julia ; Orloff, Susan ; House, Andrew A. ; Houston, Sally ; Wray, Dannah ; Huprikar, Shirish ; Johnson, Leonard B. ; Humar, Atul ; Razonable, Raymund R. ; Fisher, Robert A. ; Husain, Shahid ; Wagener, Marilyn M. ; Singh, Nina. / Identifying predictors of central nervous system disease in solid organ transplant recipientswith cryptococcosis. In: Transplantation. 2010 ; Vol. 89, No. 1. pp. 69-74.
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AU - Osawa, Ryosuke

AU - Alexander, Barbara D.

AU - Lortholary, Olivier

AU - Dromer, Françoise

AU - Forrest, Graeme N.

AU - Lyon, G. Marshall

AU - Somani, Jyoti

AU - Gupta, Krishan L.

AU - Del Busto, Ramon

AU - Pruett, Timothy L.

AU - Sifri, Costi D.

AU - Limaye, Ajit P.

AU - John, George T.

AU - Klintmalm, Goran B.

AU - Pursell, Kenneth

AU - Stosor, Valentina

AU - Morris, Michele I.

AU - Dowdy, Lorraine A.

AU - Muñoz, Patricia

AU - Kalil, Andre C.

AU - Garcia-Diaz, Julia

AU - Orloff, Susan

AU - House, Andrew A.

AU - Houston, Sally

AU - Wray, Dannah

AU - Huprikar, Shirish

AU - Johnson, Leonard B.

AU - Humar, Atul

AU - Razonable, Raymund R.

AU - Fisher, Robert A.

AU - Husain, Shahid

AU - Wagener, Marilyn M.

AU - Singh, Nina

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