Identifying hypertrophic cardiomyopathy patients by classifying individual heartbeats from 12-lead ECG signals

Quazi Abidur Rahman, Larisa G. Tereshchenko, Matthew Kongkatong, Theodore Abraham, M. Roselle Abraham, Hagit Shatkay

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    8 Scopus citations

    Abstract

    Test based on electrocardiograms (ECG) that record the heart electrical activity can help in early detection of patients with hypertrophic cardiomyopathy (HCM) where the heart muscle is partially thickened and blood flow is (potentially fatally) obstructed. This paper presents a cardiovascular-patient classifier we developed to identify HCM patients using standard 10-seconds, 12-lead ECG signals. Patients are classified as having HCM if the majority of the heartbeats are recognized as HCM. Thus, the classifier's underlying task is to recognize individual heartbeats segmented from 12-lead ECG signals as HCM beats, where heartbeats from non-HCM cardiovascular patients are used as controls. We extracted 504 morphological and temporal features - both commonly used and newly-developed ones-from ECG signals for heartbeat classification. To assess classification performance, we trained and tested a random forest classifier and a support vector machine classifier using 5-fold cross validation. The patient-classification precision of both classifiers are close to 0.85. Recall (sensitivity) and specificity are approximately 0.90. We also conducted feature selection experiments by gradually removing the least informative features; the results show that a relatively small subset of 304 highly informative features can achieve performance measures comparable to that achieved by using the complete set of features.

    Original languageEnglish (US)
    Title of host publicationProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
    EditorsHuiru Zheng, Xiaohua Tony Hu, Yadong Wang, Jin-Kao Hao, David Gilbert, Daniel Berrar, Kwang-Hyun Cho, Werner Dubitzky
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages224-229
    Number of pages6
    ISBN (Electronic)9781479956692
    DOIs
    StatePublished - Dec 29 2014
    Event2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom
    Duration: Nov 2 2014Nov 5 2014

    Publication series

    NameProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

    Other

    Other2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
    CountryUnited Kingdom
    CityBelfast
    Period11/2/1411/5/14

    Keywords

    • Electrocardiogram
    • Feature selection
    • Hypertrophic Cardiomyopathy
    • Machine learning methods
    • Patient classification

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Health Informatics

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