Identification of TP53 gene mutations in uterine corpus cancer with short follow-up

Anjila Koul, Åke Borg, Tanja Pejovic, Pär Ola Bendahl, Thomas Högberg, Constantin S. Iosif, Dick Killander

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalGynecologic oncology
Volume67
Issue number3
DOIs
StatePublished - Dec 1997

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Keywords

  • DNA ploidy
  • Mutation
  • TP53
  • Uterine corpus cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Koul, A., Borg, Å., Pejovic, T., Bendahl, P. O., Högberg, T., Iosif, C. S., & Killander, D. (1997). Identification of TP53 gene mutations in uterine corpus cancer with short follow-up. Gynecologic oncology, 67(3), 295-302. https://doi.org/10.1006/gyno.1997.4859