TY - JOUR
T1 - Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant
AU - Valentine, Peter J.
AU - Devore, Brian P.
AU - Heffron, Fred
PY - 1998/7
Y1 - 1998/7
N2 - A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the panel of routants initially chosen for this study, three mutants with comparable levels of attenuation elicited higher Salmonella-specific serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine strain. The three mutants, CL288, CL401, and CL554, also elicited a better protective immune response than the aroA control strain, after a single oral dose of 1 x 109 to 2 x 109 bacteria.
AB - A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the panel of routants initially chosen for this study, three mutants with comparable levels of attenuation elicited higher Salmonella-specific serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine strain. The three mutants, CL288, CL401, and CL554, also elicited a better protective immune response than the aroA control strain, after a single oral dose of 1 x 109 to 2 x 109 bacteria.
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U2 - 10.1128/iai.66.7.3378-3383.1998
DO - 10.1128/iai.66.7.3378-3383.1998
M3 - Article
C2 - 9632608
AN - SCOPUS:0031844796
SN - 0019-9567
VL - 66
SP - 3378
EP - 3383
JO - Infection and Immunity
JF - Infection and Immunity
IS - 7
ER -