Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant

Peter J. Valentine, Brian P. Devore, Fred Heffron

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    A panel of Salmonella typhimurium 14028s mutants, which were previously shown to be highly attenuated in the BALB/c mouse model of infection, were analyzed for their potential as live Salmonella oral-vaccine candidates. A prototypical aroA mutant was chosen as a basis of comparison. From the panel of routants initially chosen for this study, three mutants with comparable levels of attenuation elicited higher Salmonella-specific serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine strain. The three mutants, CL288, CL401, and CL554, also elicited a better protective immune response than the aroA control strain, after a single oral dose of 1 x 109 to 2 x 109 bacteria.

    Original languageEnglish (US)
    Pages (from-to)3378-3383
    Number of pages6
    JournalInfection and Immunity
    Volume66
    Issue number7
    StatePublished - Jul 1998

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    Salmonella Vaccines
    Secretory Immunoglobulin A
    Salmonella typhimurium
    Salmonella
    Vaccines
    Immunoglobulin G
    Bacteria
    Antibodies
    Infection
    Serum

    ASJC Scopus subject areas

    • Immunology

    Cite this

    Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant. / Valentine, Peter J.; Devore, Brian P.; Heffron, Fred.

    In: Infection and Immunity, Vol. 66, No. 7, 07.1998, p. 3378-3383.

    Research output: Contribution to journalArticle

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