Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: Dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells

Matthias Mayerhofer, Karl J. Aichberger, Stefan Florian, Maria Theresa Krauth, Alexander W. Hauswirth, Sophia Derdak, Wolfgang R. Sperr, Harald Esterbauer, Oswald Wagner, Christine Marosi, Winfried F. Pickl, Michael Deininger, Ellen Weisberg, Brian Druker, James D. Griffin, Christian Sillaber, Peter Valent

Research output: Contribution to journalArticle

60 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)960-962
Number of pages3
JournalFASEB Journal
Volume19
Issue number8
DOIs
StatePublished - Jun 2005
Externally publishedYes

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Neoplasm Drug Resistance
Gene expression regulation
Piperazines
bcr-abl Fusion Proteins
Cultured Tumor Cells
Dissection
Pyrimidines
Flow cytometry
G1 Phase
Gene Expression Regulation
Sirolimus
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Reverse Transcriptase Polymerase Chain Reaction
Point Mutation
Recombinant Proteins
Cell Division
Antineoplastic Agents
Protein Kinases
Vascular Endothelial Growth Factor A
Cell Survival

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia : Dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells. / Mayerhofer, Matthias; Aichberger, Karl J.; Florian, Stefan; Krauth, Maria Theresa; Hauswirth, Alexander W.; Derdak, Sophia; Sperr, Wolfgang R.; Esterbauer, Harald; Wagner, Oswald; Marosi, Christine; Pickl, Winfried F.; Deininger, Michael; Weisberg, Ellen; Druker, Brian; Griffin, James D.; Sillaber, Christian; Valent, Peter.

In: FASEB Journal, Vol. 19, No. 8, 06.2005, p. 960-962.

Research output: Contribution to journalArticle

Mayerhofer, M, Aichberger, KJ, Florian, S, Krauth, MT, Hauswirth, AW, Derdak, S, Sperr, WR, Esterbauer, H, Wagner, O, Marosi, C, Pickl, WF, Deininger, M, Weisberg, E, Druker, B, Griffin, JD, Sillaber, C & Valent, P 2005, 'Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia: Dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells', FASEB Journal, vol. 19, no. 8, pp. 960-962. https://doi.org/10.1096/fj.04-1973fje
Mayerhofer, Matthias ; Aichberger, Karl J. ; Florian, Stefan ; Krauth, Maria Theresa ; Hauswirth, Alexander W. ; Derdak, Sophia ; Sperr, Wolfgang R. ; Esterbauer, Harald ; Wagner, Oswald ; Marosi, Christine ; Pickl, Winfried F. ; Deininger, Michael ; Weisberg, Ellen ; Druker, Brian ; Griffin, James D. ; Sillaber, Christian ; Valent, Peter. / Identification of mTOR as a novel bifunctional target in chronic myeloid leukemia : Dissection of growth-inhibitory and VEGF-suppressive effects of rapamycin in leukemic cells. In: FASEB Journal. 2005 ; Vol. 19, No. 8. pp. 960-962.
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