Identification of frequent novel genetic alterations in small cell lung carcinoma

Nikki A. Levin, Pius Brzoska, Nalin Gupta, Joe Gray, Joe W. Gray, Michael F. Christman

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

We have performed a comprehensive analysis of the DNA copy number changes that occur in 18 small cell lung carcinoma cell lines using comparative genomic hybridization (Kallioniemi et al., Science (Washington DC), 258: 818- 821, 1992). DNA copy number abnormalities detected in this study include previously identified increases at 1p22-32 (L-myc), 2p24-25 (N-myc), and 8q24 (c-myc) and decreases at 17p13 (p53), 13q14 (RB), and 3p. In addition, novel DNA copy number increases were detected at 5p, 1q24, and Xq26, and novel decreases were found at 22q12.1-13.1, 10q26, and 16p11.2. Many of the most common DNA copy number changes revealed are at loci not previously recognized to be important in small cell lung cancer. In addition, a number of the DNA copy number changes, including increases at 1p22-32, 2p24-25, and 3q22-25 and a decrease on 18p, were found to occur preferentially in small cell lung carcinoma lines of the 'variant' phenotype. This correlation suggests that genes may reside at these loci whose overexpression or inactivation contributes to the radiation resistance or aggressive growth phenotypes characteristic of this subtype of small cell lung carcinoma.

Original languageEnglish (US)
Pages (from-to)5086-5091
Number of pages6
JournalCancer Research
Volume54
Issue number19
Publication statusPublished - Oct 1 1994
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Levin, N. A., Brzoska, P., Gupta, N., Gray, J., Gray, J. W., & Christman, M. F. (1994). Identification of frequent novel genetic alterations in small cell lung carcinoma. Cancer Research, 54(19), 5086-5091.