Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

HEBON Study, AOCS study group, EMBRACE Study, OPAL study group, KConFab Investigators, GEMO Study Collaborators

Research output: Contribution to journalArticle

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Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

Original languageEnglish (US)
Pages (from-to)680-691
Number of pages12
JournalNature Genetics
Volume49
Issue number5
DOIs
StatePublished - May 1 2017

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Mutation
Ovarian epithelial cancer
Regulator Genes
Ovarian Neoplasms
Genes
Meta-Analysis
Alleles
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

HEBON Study, AOCS study group, EMBRACE Study, OPAL study group, KConFab Investigators, & GEMO Study Collaborators (2017). Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nature Genetics, 49(5), 680-691. https://doi.org/10.1038/ng.3826

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. / HEBON Study; AOCS study group; EMBRACE Study; OPAL study group; KConFab Investigators; GEMO Study Collaborators.

In: Nature Genetics, Vol. 49, No. 5, 01.05.2017, p. 680-691.

Research output: Contribution to journalArticle

HEBON Study, AOCS study group, EMBRACE Study, OPAL study group, KConFab Investigators & GEMO Study Collaborators 2017, 'Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer', Nature Genetics, vol. 49, no. 5, pp. 680-691. https://doi.org/10.1038/ng.3826
HEBON Study, AOCS study group, EMBRACE Study, OPAL study group, KConFab Investigators, GEMO Study Collaborators. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nature Genetics. 2017 May 1;49(5):680-691. https://doi.org/10.1038/ng.3826
HEBON Study ; AOCS study group ; EMBRACE Study ; OPAL study group ; KConFab Investigators ; GEMO Study Collaborators. / Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. In: Nature Genetics. 2017 ; Vol. 49, No. 5. pp. 680-691.
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abstract = "To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.",
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