Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins

Paul A. Rupp, Gameil T. Fouad, Carley A. Egelston, Carol A. Reifsteck, Susan Olson, Wendy M. Knosp, Robert W. Glanville, Kent Thornburg, Susan W. Robinson, Cheryl Maslen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We have isolated and characterized a unique gene that encodes a highly conserved membrane bound extracellular protein that defines a new epidermal growth factor-related gene family. The CRELD1 (Cysteine-Rich with EGF-Like Domains 1) gene (previously known as cirrin) was cloned from a human chromosome 3 BAC. Mapping of the gene confirmed its position at chromosome 3p25.3. The gene is ubiquitously expressed in early development and later becomes more markedly expressed in the developing heart, limb buds, mandible and central nervous system. Expression persists in adulthood in most tissues. Sequence analysis suggests that this is a cell adhesion protein. The mouse orthologue was cloned and mapped to the syntenic region of mouse chromosome 6. Orthologues or homologues have also been identified for cow, Chinese hamster, Drosophila and Caenorhabditis elegans. The CRELD1 gene is deleted in the human cytogenetic disorder 3p- syndrome and is in the region of loss of heterozygosity for several types of cancer. A potential role for this protein in these disorders is discussed.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalGene
Volume293
Issue number1-2
DOIs
StatePublished - Jun 26 2002

Fingerprint

Epidermal Growth Factor
Cysteine
Messenger RNA
Genes
Proteins
Limb Buds
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 3
Loss of Heterozygosity
Chromosome Mapping
Caenorhabditis elegans
Human Chromosomes
Cricetulus
Mandible
Cell Adhesion
Cytogenetics
Drosophila
Sequence Analysis
Central Nervous System
Chromosomes

Keywords

  • Cell adhesion
  • Chromosome 3p25
  • Cirrin, EGF superfamily
  • Extracellular
  • Transmembrane domain

ASJC Scopus subject areas

  • Genetics

Cite this

Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. / Rupp, Paul A.; Fouad, Gameil T.; Egelston, Carley A.; Reifsteck, Carol A.; Olson, Susan; Knosp, Wendy M.; Glanville, Robert W.; Thornburg, Kent; Robinson, Susan W.; Maslen, Cheryl.

In: Gene, Vol. 293, No. 1-2, 26.06.2002, p. 47-57.

Research output: Contribution to journalArticle

Rupp, Paul A. ; Fouad, Gameil T. ; Egelston, Carley A. ; Reifsteck, Carol A. ; Olson, Susan ; Knosp, Wendy M. ; Glanville, Robert W. ; Thornburg, Kent ; Robinson, Susan W. ; Maslen, Cheryl. / Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. In: Gene. 2002 ; Vol. 293, No. 1-2. pp. 47-57.
@article{8c5310cbe330489a9bf4b384e13049c2,
title = "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins",
abstract = "We have isolated and characterized a unique gene that encodes a highly conserved membrane bound extracellular protein that defines a new epidermal growth factor-related gene family. The CRELD1 (Cysteine-Rich with EGF-Like Domains 1) gene (previously known as cirrin) was cloned from a human chromosome 3 BAC. Mapping of the gene confirmed its position at chromosome 3p25.3. The gene is ubiquitously expressed in early development and later becomes more markedly expressed in the developing heart, limb buds, mandible and central nervous system. Expression persists in adulthood in most tissues. Sequence analysis suggests that this is a cell adhesion protein. The mouse orthologue was cloned and mapped to the syntenic region of mouse chromosome 6. Orthologues or homologues have also been identified for cow, Chinese hamster, Drosophila and Caenorhabditis elegans. The CRELD1 gene is deleted in the human cytogenetic disorder 3p- syndrome and is in the region of loss of heterozygosity for several types of cancer. A potential role for this protein in these disorders is discussed.",
keywords = "Cell adhesion, Chromosome 3p25, Cirrin, EGF superfamily, Extracellular, Transmembrane domain",
author = "Rupp, {Paul A.} and Fouad, {Gameil T.} and Egelston, {Carley A.} and Reifsteck, {Carol A.} and Susan Olson and Knosp, {Wendy M.} and Glanville, {Robert W.} and Kent Thornburg and Robinson, {Susan W.} and Cheryl Maslen",
year = "2002",
month = "6",
day = "26",
doi = "10.1016/S0378-1119(02)00696-0",
language = "English (US)",
volume = "293",
pages = "47--57",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins

AU - Rupp, Paul A.

AU - Fouad, Gameil T.

AU - Egelston, Carley A.

AU - Reifsteck, Carol A.

AU - Olson, Susan

AU - Knosp, Wendy M.

AU - Glanville, Robert W.

AU - Thornburg, Kent

AU - Robinson, Susan W.

AU - Maslen, Cheryl

PY - 2002/6/26

Y1 - 2002/6/26

N2 - We have isolated and characterized a unique gene that encodes a highly conserved membrane bound extracellular protein that defines a new epidermal growth factor-related gene family. The CRELD1 (Cysteine-Rich with EGF-Like Domains 1) gene (previously known as cirrin) was cloned from a human chromosome 3 BAC. Mapping of the gene confirmed its position at chromosome 3p25.3. The gene is ubiquitously expressed in early development and later becomes more markedly expressed in the developing heart, limb buds, mandible and central nervous system. Expression persists in adulthood in most tissues. Sequence analysis suggests that this is a cell adhesion protein. The mouse orthologue was cloned and mapped to the syntenic region of mouse chromosome 6. Orthologues or homologues have also been identified for cow, Chinese hamster, Drosophila and Caenorhabditis elegans. The CRELD1 gene is deleted in the human cytogenetic disorder 3p- syndrome and is in the region of loss of heterozygosity for several types of cancer. A potential role for this protein in these disorders is discussed.

AB - We have isolated and characterized a unique gene that encodes a highly conserved membrane bound extracellular protein that defines a new epidermal growth factor-related gene family. The CRELD1 (Cysteine-Rich with EGF-Like Domains 1) gene (previously known as cirrin) was cloned from a human chromosome 3 BAC. Mapping of the gene confirmed its position at chromosome 3p25.3. The gene is ubiquitously expressed in early development and later becomes more markedly expressed in the developing heart, limb buds, mandible and central nervous system. Expression persists in adulthood in most tissues. Sequence analysis suggests that this is a cell adhesion protein. The mouse orthologue was cloned and mapped to the syntenic region of mouse chromosome 6. Orthologues or homologues have also been identified for cow, Chinese hamster, Drosophila and Caenorhabditis elegans. The CRELD1 gene is deleted in the human cytogenetic disorder 3p- syndrome and is in the region of loss of heterozygosity for several types of cancer. A potential role for this protein in these disorders is discussed.

KW - Cell adhesion

KW - Chromosome 3p25

KW - Cirrin, EGF superfamily

KW - Extracellular

KW - Transmembrane domain

UR - http://www.scopus.com/inward/record.url?scp=0037178268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037178268&partnerID=8YFLogxK

U2 - 10.1016/S0378-1119(02)00696-0

DO - 10.1016/S0378-1119(02)00696-0

M3 - Article

C2 - 12137942

AN - SCOPUS:0037178268

VL - 293

SP - 47

EP - 57

JO - Gene

JF - Gene

SN - 0378-1119

IS - 1-2

ER -