Identification and Significance of Multinucleate Tumor Cells In Retinoblastoma

Martha A. Howard, Thaddeus P. Dryja, Daniel Albert, David S. Walton

Research output: Contribution to journalArticle

6 Scopus citations


Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.

Original languageEnglish (US)
Pages (from-to)1025-1030
Number of pages6
JournalArchives of ophthalmology
Issue number7
Publication statusPublished - Jan 1 1989
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

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