Identification and Significance of Multinucleate Tumor Cells In Retinoblastoma

Martha A. Howard, Thaddeus P. Dryja, Daniel Albert, David S. Walton

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.

Original languageEnglish (US)
Pages (from-to)1025-1030
Number of pages6
JournalArchives of ophthalmology
Volume107
Issue number7
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Retinoblastoma
Retinal Neoplasms
Neoplasms
Nude Mice
Cell Differentiation
Electron Microscopy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Identification and Significance of Multinucleate Tumor Cells In Retinoblastoma. / Howard, Martha A.; Dryja, Thaddeus P.; Albert, Daniel; Walton, David S.

In: Archives of ophthalmology, Vol. 107, No. 7, 01.01.1989, p. 1025-1030.

Research output: Contribution to journalArticle

Howard, Martha A. ; Dryja, Thaddeus P. ; Albert, Daniel ; Walton, David S. / Identification and Significance of Multinucleate Tumor Cells In Retinoblastoma. In: Archives of ophthalmology. 1989 ; Vol. 107, No. 7. pp. 1025-1030.
@article{1d196bec75d64f20a2243cc4faec0fa7,
title = "Identification and Significance of Multinucleate Tumor Cells In Retinoblastoma",
abstract = "Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.",
author = "Howard, {Martha A.} and Dryja, {Thaddeus P.} and Daniel Albert and Walton, {David S.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1001/archopht.1989.01070020087037",
language = "English (US)",
volume = "107",
pages = "1025--1030",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Identification and Significance of Multinucleate Tumor Cells In Retinoblastoma

AU - Howard, Martha A.

AU - Dryja, Thaddeus P.

AU - Albert, Daniel

AU - Walton, David S.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.

AB - Multinucleate tumor cells were observed in a case of a retinal tumor suspected to be a retinoma (retinocytoma). On electron microscopy, these cells had characteristics of retinoblastoma. Similar cells were observed in an irradiated model of retinoblastoma grown in a nude mouse. We suggest that the presence of these cells indicates differentiation and/or regression of the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0024413877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024413877&partnerID=8YFLogxK

U2 - 10.1001/archopht.1989.01070020087037

DO - 10.1001/archopht.1989.01070020087037

M3 - Article

VL - 107

SP - 1025

EP - 1030

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 7

ER -