Abstract
Gamma-endorphin (gamma E) and related peptides were chromatographically identified in extracts of neurointermediate (NIL) pituitary. When extracts of this tissue were purified and subjected to HPLC in order to identify gamma E-related peptides gamma E, des-tyrosine gamma E, des-enkephalin-gamma E, and alpha-N acetyl gamma E co-elutable peptides were evident. Perifusates of dispersed NIL tissue were also shown to contain beta E and gamma E-immunoreactivity, and the secretion of both was suppressed by exposure of the tissue to dopamine. This study provides evidence of the endogenous presence and secretion of pharmacologically active gamma E-related peptides by the intermediate lobe of the rat pituitary.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 285-292 |
| Number of pages | 8 |
| Journal | Progress in Clinical and Biological Research |
| Volume | 192 |
| State | Published - 1985 |
| Externally published | Yes |
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Identification and secretion of gamma-endorphin and beta-endorphin-like peptides from the neurointermediate pituitary of the rat. / Dorsa, Daniel; Keith, L. D.
In: Progress in Clinical and Biological Research, Vol. 192, 1985, p. 285-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification and secretion of gamma-endorphin and beta-endorphin-like peptides from the neurointermediate pituitary of the rat.
AU - Dorsa, Daniel
AU - Keith, L. D.
PY - 1985
Y1 - 1985
N2 - Gamma-endorphin (gamma E) and related peptides were chromatographically identified in extracts of neurointermediate (NIL) pituitary. When extracts of this tissue were purified and subjected to HPLC in order to identify gamma E-related peptides gamma E, des-tyrosine gamma E, des-enkephalin-gamma E, and alpha-N acetyl gamma E co-elutable peptides were evident. Perifusates of dispersed NIL tissue were also shown to contain beta E and gamma E-immunoreactivity, and the secretion of both was suppressed by exposure of the tissue to dopamine. This study provides evidence of the endogenous presence and secretion of pharmacologically active gamma E-related peptides by the intermediate lobe of the rat pituitary.
AB - Gamma-endorphin (gamma E) and related peptides were chromatographically identified in extracts of neurointermediate (NIL) pituitary. When extracts of this tissue were purified and subjected to HPLC in order to identify gamma E-related peptides gamma E, des-tyrosine gamma E, des-enkephalin-gamma E, and alpha-N acetyl gamma E co-elutable peptides were evident. Perifusates of dispersed NIL tissue were also shown to contain beta E and gamma E-immunoreactivity, and the secretion of both was suppressed by exposure of the tissue to dopamine. This study provides evidence of the endogenous presence and secretion of pharmacologically active gamma E-related peptides by the intermediate lobe of the rat pituitary.
UR - http://www.scopus.com/inward/record.url?scp=0022322115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022322115&partnerID=8YFLogxK
M3 - Article
C2 - 2417252
AN - SCOPUS:0022322115
VL - 192
SP - 285
EP - 292
JO - Progress in Clinical and Biological Research
JF - Progress in Clinical and Biological Research
SN - 0361-7742
ER -