Identification and function of human cytomegalovirus microRNAs

Finn Grey, Jay Nelson

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

microRNAs are an extensive class of non-coding genes that regulate gene expression through post-transcriptional repression. These small RNAs are evolutionarily conserved and are likely to be a basic mechanism of gene regulation present within most eukaryotic organisms. Over 100 viral miRNAs have been identified to date through a combination of bioinformatics and cloning studies. In this review we discuss the use of bioinformatics for the identification of HCMV miRNAs and also for the discovery of potential target transcripts. Such studies will enable us to define the functional role of viral miRNAs and gain a better understanding of viral gene regulation.

Original languageEnglish (US)
Pages (from-to)186-191
Number of pages6
JournalJournal of Clinical Virology
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2008

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Keywords

  • Cytomegalovirus
  • Human
  • IE72
  • Latency
  • Virus
  • microRNA

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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