Identification and Characterization of the Hamster Polyomavirus Middle T Antigen

Sara Courtneidge, Laurence Goutebroze, Andrew Cartwright, Angelika Heber, Siegfried Scherneck, Jean Feunteun

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Hamster polyomavirus (HaPV) is associated with lymphoid and hair follicle tumors in Syrian hamsters. The early region of HaPV has the potential to encode three polypeptides (which are related to the mouse polyomavirus early proteins) and can transform fibroblasts in vitro. We identified the HaPV middle T antigen (HamT) as a 45-kDa protein. Like its murine counterpart, HamT was associated with serine/threonine phosphatase, phosphatidylinositol-3 kinase, and protein tyrosine kinase activities. However, whereas mouse middle T antigen associates predominantly with pp60c-src and pp62c-yes, HamT was associated with a different tyrosine kinase, p59fyn. The ability of HaPV to cause lymphoid tumors may therefore reside in its ability to associate with p59fyn, a potentially important tyrosine kinase in lymphocytes.

Original languageEnglish (US)
Pages (from-to)3301-3308
Number of pages8
JournalJournal of Virology
Volume65
Issue number6
StatePublished - Jun 1991
Externally publishedYes

Fingerprint

Hamster polyomavirus
Polyomavirus Transforming Antigens
Polyomavirus
antigens
Viral Tumor Antigens
Protein-Tyrosine Kinases
Murine polyomavirus
tyrosine
phosphotransferases (kinases)
hair follicles
neoplasms
protein-tyrosine kinases
Phosphatidylinositol 3-Kinase
mice
phosphatidylinositol 3-kinase
threonine
Hair Follicle
serine
Phosphoprotein Phosphatases
fibroblasts

ASJC Scopus subject areas

  • Immunology

Cite this

Courtneidge, S., Goutebroze, L., Cartwright, A., Heber, A., Scherneck, S., & Feunteun, J. (1991). Identification and Characterization of the Hamster Polyomavirus Middle T Antigen. Journal of Virology, 65(6), 3301-3308.

Identification and Characterization of the Hamster Polyomavirus Middle T Antigen. / Courtneidge, Sara; Goutebroze, Laurence; Cartwright, Andrew; Heber, Angelika; Scherneck, Siegfried; Feunteun, Jean.

In: Journal of Virology, Vol. 65, No. 6, 06.1991, p. 3301-3308.

Research output: Contribution to journalArticle

Courtneidge, S, Goutebroze, L, Cartwright, A, Heber, A, Scherneck, S & Feunteun, J 1991, 'Identification and Characterization of the Hamster Polyomavirus Middle T Antigen', Journal of Virology, vol. 65, no. 6, pp. 3301-3308.
Courtneidge S, Goutebroze L, Cartwright A, Heber A, Scherneck S, Feunteun J. Identification and Characterization of the Hamster Polyomavirus Middle T Antigen. Journal of Virology. 1991 Jun;65(6):3301-3308.
Courtneidge, Sara ; Goutebroze, Laurence ; Cartwright, Andrew ; Heber, Angelika ; Scherneck, Siegfried ; Feunteun, Jean. / Identification and Characterization of the Hamster Polyomavirus Middle T Antigen. In: Journal of Virology. 1991 ; Vol. 65, No. 6. pp. 3301-3308.
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