Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24

Laura Carim-Todd; Lauro Sumoy; Nuria Andreu; Xavier Estivill; Mònica Escarceller

doi:10.1016/S0378-1119(00)00513-8

Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24

Laura Carim-Todd, Lauro Sumoy, Nuria Andreu, Xavier Estivill, Mònica Escarceller

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Working within the EUROIMAGE full-length cDNA sequencing project we have isolated BTBD1, a novel human gene with a BTB/POZ domain. This motif is found in developmentally regulated zinc finger proteins and in the kelch family of actin-associated proteins, and is thought to mediate protein-protein interactions. The BTBD1 gene encodes a transcript of 3188 nt with an ORF of 482 amino acids and a predicted protein product size of 52.7 kDa. Northern blot analysis revealed an enhanced BTBD1 expression in heart and skeletal muscle. We have identified a paralogous BTBD1 counterpart gene on chromosome 19, BTBD2. BTBD1 was mapped to chromosome 15q24. Conservation of multiple pairs of genes between 15q24 and 19p13.3-p12 suggests their possible common chromosomal origin. We show the existence of the murine BTBD1 and BTBD2 orthologous genes, as well as the partial rat and bovine homologs.

Original language	English (US)
Pages (from-to)	275-281
Number of pages	7
Journal	Gene
Volume	262
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(00)00513-8
State	Published - Jan 10 2001
Externally published	Yes

Keywords

15q24
19p
BTB (POZ) domain containing 1
EUROIMAGE

ASJC Scopus subject areas

Genetics

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10.1016/S0378-1119(00)00513-8

Cite this

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title = "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24",

abstract = "Working within the EUROIMAGE full-length cDNA sequencing project we have isolated BTBD1, a novel human gene with a BTB/POZ domain. This motif is found in developmentally regulated zinc finger proteins and in the kelch family of actin-associated proteins, and is thought to mediate protein-protein interactions. The BTBD1 gene encodes a transcript of 3188 nt with an ORF of 482 amino acids and a predicted protein product size of 52.7 kDa. Northern blot analysis revealed an enhanced BTBD1 expression in heart and skeletal muscle. We have identified a paralogous BTBD1 counterpart gene on chromosome 19, BTBD2. BTBD1 was mapped to chromosome 15q24. Conservation of multiple pairs of genes between 15q24 and 19p13.3-p12 suggests their possible common chromosomal origin. We show the existence of the murine BTBD1 and BTBD2 orthologous genes, as well as the partial rat and bovine homologs.",

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author = "Laura Carim-Todd and Lauro Sumoy and Nuria Andreu and Xavier Estivill and M{\`o}nica Escarceller",

note = "Funding Information: We are grateful to A. Puig and D. Otero for technical support with DNA sequencing. We wish to thank the HGMP Resource Center in Hinxton, UK, and the RZPD in Berlin, Germany, for supplying us with IMAGE cDNA clones. This work has been supported by EU Biomed Project No. BMH4-CT97-2284 to X. E and by CICYT-IN95-0347. M.E. is funded by the Spanish Ministry of Education (CIDYT contract FPI-070-97) and L.S. by the Catalan autonomous government (CIRIT-RED contract 1998-64).",

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doi = "10.1016/S0378-1119(00)00513-8",

language = "English (US)",

volume = "262",

pages = "275--281",

journal = "Gene",

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AU - Sumoy, Lauro

AU - Andreu, Nuria

AU - Estivill, Xavier

AU - Escarceller, Mònica

N1 - Funding Information: We are grateful to A. Puig and D. Otero for technical support with DNA sequencing. We wish to thank the HGMP Resource Center in Hinxton, UK, and the RZPD in Berlin, Germany, for supplying us with IMAGE cDNA clones. This work has been supported by EU Biomed Project No. BMH4-CT97-2284 to X. E and by CICYT-IN95-0347. M.E. is funded by the Spanish Ministry of Education (CIDYT contract FPI-070-97) and L.S. by the Catalan autonomous government (CIRIT-RED contract 1998-64).

PY - 2001/1/10

Y1 - 2001/1/10

N2 - Working within the EUROIMAGE full-length cDNA sequencing project we have isolated BTBD1, a novel human gene with a BTB/POZ domain. This motif is found in developmentally regulated zinc finger proteins and in the kelch family of actin-associated proteins, and is thought to mediate protein-protein interactions. The BTBD1 gene encodes a transcript of 3188 nt with an ORF of 482 amino acids and a predicted protein product size of 52.7 kDa. Northern blot analysis revealed an enhanced BTBD1 expression in heart and skeletal muscle. We have identified a paralogous BTBD1 counterpart gene on chromosome 19, BTBD2. BTBD1 was mapped to chromosome 15q24. Conservation of multiple pairs of genes between 15q24 and 19p13.3-p12 suggests their possible common chromosomal origin. We show the existence of the murine BTBD1 and BTBD2 orthologous genes, as well as the partial rat and bovine homologs.

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Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24

Abstract

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