TY - JOUR
T1 - Identifiability Analysis of an In Vivo Receptor-Binding Radiopharmacokinetic System
AU - Vera, David R.
AU - Krohn, Kenneth A.
AU - Scheibe, Paul O.
AU - Stadalnik, Robert C.
PY - 1985/5
Y1 - 1985/5
N2 - A five-state, nonlinear model describing the pharmacokinetics of a receptor-binding radiopharmaceutical is presented. Local parameter identifiability analysis was performed preexperimentally to investigate the chemical and observational conditions required for adequate estimates of hepatic blood flow, receptor-ligand affinity, and receptor population. The ability to estimate the above parameters from externally observed kinetic data depended upon receptor-ligand affinity, the molar dose of the radiopharmaceutical, the number and coupling of the observers, and independent knowledge of the coupling coefficients or ligand-receptor affinity.
AB - A five-state, nonlinear model describing the pharmacokinetics of a receptor-binding radiopharmaceutical is presented. Local parameter identifiability analysis was performed preexperimentally to investigate the chemical and observational conditions required for adequate estimates of hepatic blood flow, receptor-ligand affinity, and receptor population. The ability to estimate the above parameters from externally observed kinetic data depended upon receptor-ligand affinity, the molar dose of the radiopharmaceutical, the number and coupling of the observers, and independent knowledge of the coupling coefficients or ligand-receptor affinity.
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U2 - 10.1109/TBME.1985.325544
DO - 10.1109/TBME.1985.325544
M3 - Article
C2 - 3997184
AN - SCOPUS:0021890394
SN - 0018-9294
VL - BME-32
SP - 312
EP - 322
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 5
ER -