Identifiability Analysis of an In Vivo Receptor-Binding Radiopharmacokinetic System

David R. Vera, Kenneth A. Krohn, Paul O. Scheibe, Robert C. Stadalnik

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

A five-state, nonlinear model describing the pharmacokinetics of a receptor-binding radiopharmaceutical is presented. Local parameter identifiability analysis was performed preexperimentally to investigate the chemical and observational conditions required for adequate estimates of hepatic blood flow, receptor-ligand affinity, and receptor population. The ability to estimate the above parameters from externally observed kinetic data depended upon receptor-ligand affinity, the molar dose of the radiopharmaceutical, the number and coupling of the observers, and independent knowledge of the coupling coefficients or ligand-receptor affinity.

Original languageEnglish (US)
Pages (from-to)312-322
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
VolumeBME-32
Issue number5
DOIs
StatePublished - May 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering

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