Identifiability Analysis of an In Vivo Receptor-Binding Radiopharmacokinetic System

David R. Vera, Kenneth Krohn, Paul O. Scheibe, Robert C. Stadalnik

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

A five-state, nonlinear model describing the pharmacokinetics of a receptor-binding radiopharmaceutical is presented. Local parameter identifiability analysis was performed preexperimentally to investigate the chemical and observational conditions required for adequate estimates of hepatic blood flow, receptor-ligand affinity, and receptor population. The ability to estimate the above parameters from externally observed kinetic data depended upon receptor-ligand affinity, the molar dose of the radiopharmaceutical, the number and coupling of the observers, and independent knowledge of the coupling coefficients or ligand-receptor affinity.

Original languageEnglish (US)
Pages (from-to)312-322
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
VolumeBME-32
Issue number5
DOIs
StatePublished - 1985
Externally publishedYes

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Ligands
Pharmacokinetics
Blood
Kinetics

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Identifiability Analysis of an In Vivo Receptor-Binding Radiopharmacokinetic System. / Vera, David R.; Krohn, Kenneth; Scheibe, Paul O.; Stadalnik, Robert C.

In: IEEE Transactions on Biomedical Engineering, Vol. BME-32, No. 5, 1985, p. 312-322.

Research output: Contribution to journalArticle

Vera, David R. ; Krohn, Kenneth ; Scheibe, Paul O. ; Stadalnik, Robert C. / Identifiability Analysis of an In Vivo Receptor-Binding Radiopharmacokinetic System. In: IEEE Transactions on Biomedical Engineering. 1985 ; Vol. BME-32, No. 5. pp. 312-322.
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