Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis

Matthew C. Havrda, Brent T. Harris, Akio Mantani, Nora M. Ward, Brenton R. Paolella, Verginia Cuzon Carlson, Hermes H. Yeh, Mark A. Israel

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Understanding the biology of adult neural stem cells has important implications for nervous system development and may contribute to our understanding of neurodegenerative disorders and their treatment. We have characterized the process of olfactory neurogenesis in adult mice lacking inhibitor of DNA binding 2-/- (Id2-/-). We found a diminished olfactory bulb containing reduced numbers of granular and periglomerular neurons with a distinct paucity of dopaminergic periglomerular neurons. While no deficiency of the stem cell compartment was detectable, migrating neuroblasts in Id2-/- mutant mice prematurely undergo astroglial differentiation within a disorganized rostral migratory stream. Further, when evaluated in vitro loss of Id2 results in decreased proliferation of neural progenitors and decreased expression of the Hes1 and Ascl1 (Mash1) transcription factors, known mediators of neuronal differentiation. These data support a novel role for sustained Id2 expression in migrating neural progenitors mediating olfactory dopaminergic neuronal differentiation in adult animals.

Original languageEnglish (US)
Pages (from-to)14074-14086
Number of pages13
JournalJournal of Neuroscience
Volume28
Issue number52
DOIs
StatePublished - Dec 24 2008
Externally publishedYes

Fingerprint

Dopaminergic Neurons
Neurogenesis
Adult Stem Cells
Neural Stem Cells
Olfactory Bulb
DNA
Neurodegenerative Diseases
Nervous System
Transcription Factors
Stem Cells
Neurons
In Vitro Techniques

Keywords

  • Adult
  • Dopaminergic
  • Id2
  • Neurogenesis
  • Olfactory
  • Subventricular zone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Havrda, M. C., Harris, B. T., Mantani, A., Ward, N. M., Paolella, B. R., Cuzon Carlson, V., ... Israel, M. A. (2008). Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. Journal of Neuroscience, 28(52), 14074-14086. https://doi.org/10.1523/JNEUROSCI.3188-08.2008

Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. / Havrda, Matthew C.; Harris, Brent T.; Mantani, Akio; Ward, Nora M.; Paolella, Brenton R.; Cuzon Carlson, Verginia; Yeh, Hermes H.; Israel, Mark A.

In: Journal of Neuroscience, Vol. 28, No. 52, 24.12.2008, p. 14074-14086.

Research output: Contribution to journalArticle

Havrda, MC, Harris, BT, Mantani, A, Ward, NM, Paolella, BR, Cuzon Carlson, V, Yeh, HH & Israel, MA 2008, 'Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis', Journal of Neuroscience, vol. 28, no. 52, pp. 14074-14086. https://doi.org/10.1523/JNEUROSCI.3188-08.2008
Havrda, Matthew C. ; Harris, Brent T. ; Mantani, Akio ; Ward, Nora M. ; Paolella, Brenton R. ; Cuzon Carlson, Verginia ; Yeh, Hermes H. ; Israel, Mark A. / Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 52. pp. 14074-14086.
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